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- W1569114860 abstract "Publisher Summary The 13 C nuclear magnetic resonance (NMR) spectroscopy is ideally suited for the study of metabolism. The major advantage of 13 C NMR over conventional radioisotope-labeling studies is its ability to distinguish which carbons in a particular metabolite are labeled without complex extraction and metabolite isolation procedures. These properties have made 13 C NMR particularly useful in the study of folate-mediated one-carbon metabolism. In this chapter, the yeast Saccharomyces cerevisiae is chosen as a eukaryotic model to study the compartmentation of folate-mediated one-carbon metabolism. Saccharomyces cerevisiae provides a tremendously powerful system to study these pathways. The genes for all of the reactions have been cloned from Saccharomyces , facilitating the construction of defined mutations in these genes. The basic approach is to create blocks at specific steps in the one-carbon pathway and examine the resulting metabolic effects of the blocks. The analytical power of 13 C NMR, used in combination with yeast strains harboring specific metabolic blocks, enables the enzymatic route and compartment of biosynthesis of a given metabolite to be determined. The principle of this method is to label metabolically the one-carbon pools with 13 C-labeled one-carbon donors, such as serine, glycine, or formate, followed by NMR analysis of metabolic end products." @default.
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- W1569114860 date "1997-01-01" @default.
- W1569114860 modified "2023-09-24" @default.
- W1569114860 title "Use of 13C nuclear magnetic resonance to evaluate metabolic flux through folate one-carbon pools in Saccharomyces cerevisiae" @default.
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- W1569114860 doi "https://doi.org/10.1016/s0076-6879(97)81028-2" @default.
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