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- W1569122461 abstract "We previously observed marked down-regulation of the mRNA for angiogenin, a potent inducer of neovascularization, in a mouse model of Parkinson's disease (PD) based on over-expression of alpha-synuclein. Angiogenin has also been recently implicated in the pathogenesis of amyotrophic lateral sclerosis. In this study, we confirmed that mouse angiogenin-1 protein is dramatically reduced in this transgenic alpha-synuclein mouse model of PD, and examined the effect of angiogenin in cellular models of PD. We found that endogenous angiogenin is present in two dopamine-producing neuroblastoma cell lines, SH-SY5Y and M17, and that exogenous angiogenin is taken up by these cells and leads to phosphorylation of Akt. Applied angiogenin protects against the cell death induced by the neurotoxins 1-methyl-4-phenylpyridinium and rotenone and reduces the activation of caspase 3. Together our data supports the importance of angiogenin in protecting against dopaminergic neuronal cell death and suggests its potential as a therapy for PD." @default.
- W1569122461 created "2016-06-24" @default.
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- W1569122461 creator A5031000185 @default.
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- W1569122461 date "2010-12-22" @default.
- W1569122461 modified "2023-10-13" @default.
- W1569122461 title "A neuroprotective role for angiogenin in models of Parkinson’s disease" @default.
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- W1569122461 doi "https://doi.org/10.1111/j.1471-4159.2010.07112.x" @default.
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