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• W1569130359 abstract "8 Tiivistelma 10 Abbreviations and a mini-glossary 12 Original publications 17 Review of the literature 18 1. Innate immunity: the primary sensor of self and non-self 18 1.1. Cells of the innate immunity 18 1.1.1 Professional phagocytes and antigen presenting cells (APCs) 20 1.2. Activation of innate immunity by pathogenic microbes: pathogen associated molecular patterns (PAMPs) 21 1.2.1. Viral PAMPs 22 1.2.1.1. Double-stranded RNA (dsRNA) 23 1.3. Activation of innate immunity by endogenous host molecules: danger associated molecular patterns (DAMPs) 25 1.4. Pattern recognition receptors (PRRs) 25 1.4.1. Toll-like receptors (TLRs) 26 1.4.1.1. Nucleic acid-sensing TLRs in viral recognition 28 1.4.2. Retinoic acid-inducible gene-I (RIG-I) -like receptors (RLRs) 28 1.4.2.1 RNA recognition of RIG-I and MDA-5 29 1.4.3. Nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) and inflammasomes 31 1.4.3.1. NLRP3-inflammasome 32 1.4.3.2. Inflammasomes in virus recognition 33 1.5. Other dsRNA-activated effector proteins of the innate immunity 34 1.5.1. Double-stranded RNA-activated Protein kinase (PKR) 34 1.5.2. 2'-5'-oligoadenylate synthetase (2'-5'OAS) and ribonuclease-L (RNAseL) system 34 1.5.3. Mx protein A (MxA) 35 2. Innate immune responses against viruses 35 2.1. Antiviral cytokine response: Interferons (IFNs) 35 2.1.1. Systemic and context-specific effects of IFN-/ 36 2.1.2. Induction of IFN-/: two phases 37 2.1.3.1 IFN-/ production mediated through TLRs 38 2.1.3.2 IFN-/ production mediated through RLRs 39 2.2. Virus-induced pro-inflammatory cytokine response 40 2.2.1. IL-1 family of pro-inflammatory cytokines 41 2.2.2. Systemic effects of IL-1 and IL-18 42 2.2.3. Production of IL-1 and IL-18: two phases 43" @default.
• W1569130359 created "2016-06-24" @default.
• W1569130359 creator A5020149531 @default.
• W1569130359 date "2011-06-17" @default.
• W1569130359 modified "2023-09-25" @default.
• W1569130359 title "Innate Immune Recognition of RNA-virus infection in human macrophages" @default.
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