FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1569138725> ?p ?o ?g. }

• W1569138725 endingPage "270" @default.
• W1569138725 startingPage "265" @default.
• W1569138725 abstract "The vitamin D receptor (VDR) is a critical mediator of the biological actions of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3). As a nuclear receptor, ligand activation of the VDR leads to the protein's binding to specific sites on the genome that results in the modulation of target gene expression. The VDR is also known to play a role in the hair cycle, an action that appears to be 1,25(OH)2D3-independent. Indeed, in the absence of the VDR as in hereditary 1,25-dihydroxyvitamin D resistant rickets (HVDRR) both skin defects and alopecia emerge. Recently, we generated a mouse model of HVDRR without alopecia wherein a mutant human VDR lacking 1,25(OH)2D3-binding activity was expressed in the absence of endogenous mouse VDR. While 1,25(OH)2D3 failed to induce gene expression in these mice, resulting in an extensive skeletal phenotype, the receptor was capable of restoring normal hair cycling. We also noted a level of secondary hyperparathyroidism that was much higher than that seen in the VDR null mouse and was associated with an exaggerated bone phenotype as well. This suggested that the VDR might play a role in parathyroid hormone (PTH) regulation independent of 1,25(OH)2D3. To evaluate this hypothesis further, we contrasted PTH levels in the HVDRR mouse model with those seen in Cyp27b1 null mice where the VDR was present but the hormone was absent. The data revealed that PTH was indeed higher in Cyp27b1 null mice compared to VDR null mice. To evaluate the mechanism of action underlying such a hypothesis, we measured the expression levels of a number of VDR target genes in the duodena of wildtype mice and in transgenic mice expressing either normal or hormone-binding deficient mutant VDRs. We also compared expression levels of these genes between VDR null mice and Cyp27b1 null mice. In a subset of cases, the expression of VDR target genes was lower in mice containing the VDR as opposed to mice that did not. We suggest that the VDR may function as a selective suppressor/de-repressor of gene expression in the absence of 1,25(OH)2D3." @default.
• W1569138725 created "2016-06-24" @default.
• W1569138725 creator A5024190744 @default.
• W1569138725 creator A5049270000 @default.
• W1569138725 date "2016-11-01" @default.
• W1569138725 modified "2023-10-02" @default.
• W1569138725 title "The vitamin D receptor functions as a transcription regulator in the absence of 1,25-dihydroxyvitamin D3" @default.
• W1569138725 cites W1484617378 @default.
• W1569138725 cites W1966209014 @default.
• W1569138725 cites W1967615088 @default.
• W1569138725 cites W1986500372 @default.
• W1569138725 cites W1989700145 @default.
• W1569138725 cites W1991512077 @default.
• W1569138725 cites W1993967111 @default.
• W1569138725 cites W1995754186 @default.
• W1569138725 cites W2001523917 @default.
• W1569138725 cites W2001884779 @default.
• W1569138725 cites W2004473236 @default.
• W1569138725 cites W2008790622 @default.
• W1569138725 cites W2017019792 @default.
• W1569138725 cites W2017290177 @default.
• W1569138725 cites W2018809127 @default.
• W1569138725 cites W2024160556 @default.
• W1569138725 cites W2030935023 @default.
• W1569138725 cites W2035981852 @default.
• W1569138725 cites W2036080863 @default.
• W1569138725 cites W2037133484 @default.
• W1569138725 cites W2037276007 @default.
• W1569138725 cites W2039871782 @default.
• W1569138725 cites W2040959543 @default.
• W1569138725 cites W2044787531 @default.
• W1569138725 cites W2046473453 @default.
• W1569138725 cites W2057458147 @default.
• W1569138725 cites W2074559070 @default.
• W1569138725 cites W2076732626 @default.
• W1569138725 cites W2089518544 @default.
• W1569138725 cites W2097191932 @default.
• W1569138725 cites W2097246067 @default.
• W1569138725 cites W2114849059 @default.
• W1569138725 cites W2126050914 @default.
• W1569138725 cites W2148772545 @default.
• W1569138725 cites W2155746549 @default.
• W1569138725 cites W2172256092 @default.
• W1569138725 cites W2616314504 @default.
• W1569138725 doi "https://doi.org/10.1016/j.jsbmb.2015.08.018" @default.
• W1569138725 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4769962" @default.
• W1569138725 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26323657" @default.
• W1569138725 hasPublicationYear "2016" @default.
• W1569138725 type Work @default.
• W1569138725 sameAs 1569138725 @default.
• W1569138725 citedByCount "26" @default.
• W1569138725 countsByYear W15691387252015 @default.
• W1569138725 countsByYear W15691387252016 @default.
• W1569138725 countsByYear W15691387252017 @default.
• W1569138725 countsByYear W15691387252018 @default.
• W1569138725 countsByYear W15691387252019 @default.
• W1569138725 countsByYear W15691387252020 @default.
• W1569138725 countsByYear W15691387252021 @default.
• W1569138725 countsByYear W15691387252022 @default.
• W1569138725 countsByYear W15691387252023 @default.
• W1569138725 crossrefType "journal-article" @default.
• W1569138725 hasAuthorship W1569138725A5024190744 @default.
• W1569138725 hasAuthorship W1569138725A5049270000 @default.
• W1569138725 hasBestOaLocation W15691387252 @default.
• W1569138725 hasConcept C104317684 @default.
• W1569138725 hasConcept C124490489 @default.
• W1569138725 hasConcept C126322002 @default.
• W1569138725 hasConcept C134018914 @default.
• W1569138725 hasConcept C170493617 @default.
• W1569138725 hasConcept C179639408 @default.
• W1569138725 hasConcept C2776489590 @default.
• W1569138725 hasConcept C2781208988 @default.
• W1569138725 hasConcept C519063684 @default.
• W1569138725 hasConcept C54355233 @default.
• W1569138725 hasConcept C63932345 @default.
• W1569138725 hasConcept C71924100 @default.
• W1569138725 hasConcept C86339819 @default.
• W1569138725 hasConcept C86803240 @default.
• W1569138725 hasConceptScore W1569138725C104317684 @default.
• W1569138725 hasConceptScore W1569138725C124490489 @default.
• W1569138725 hasConceptScore W1569138725C126322002 @default.
• W1569138725 hasConceptScore W1569138725C134018914 @default.
• W1569138725 hasConceptScore W1569138725C170493617 @default.
• W1569138725 hasConceptScore W1569138725C179639408 @default.
• W1569138725 hasConceptScore W1569138725C2776489590 @default.
• W1569138725 hasConceptScore W1569138725C2781208988 @default.
• W1569138725 hasConceptScore W1569138725C519063684 @default.
• W1569138725 hasConceptScore W1569138725C54355233 @default.
• W1569138725 hasConceptScore W1569138725C63932345 @default.
• W1569138725 hasConceptScore W1569138725C71924100 @default.
• W1569138725 hasConceptScore W1569138725C86339819 @default.
• W1569138725 hasConceptScore W1569138725C86803240 @default.
• W1569138725 hasLocation W15691387251 @default.
• W1569138725 hasLocation W15691387252 @default.
• W1569138725 hasLocation W15691387253 @default.
• W1569138725 hasLocation W15691387254 @default.
• W1569138725 hasOpenAccess W1569138725 @default.
• W1569138725 hasPrimaryLocation W15691387251 @default.

• next