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- W1569141172 abstract "Hereditary nonpolyposis colorectal cancer (HNPCC) is common, accounting for about 4–6% of the total colorectal cancer burden. It is heterogeneous and appears to be delineated into two clinical subsets, Lynch syndromes I and II. Lynch syndrome I is characterized by an autosomal dominantly inherited proclivity to early onset colonic cancer with proximal predominance and an excess of multiple primary colonic cancer. Lynch syndrome II has all of these features plus extracolonic cancer sites, the most common of which is endometrial carcinoma. The lack of premonitory physical signs or biomarkers of HNPCC makes diagnosis difficult. A careful family history, tempered by an understanding of the clinical and pathologic features of HNPCC, is the key to its assessment. This paper reviews HNPCC's natural history, its integral extracolonic cancer associations, its differential diagnosis, surveillance, and management strategies. Attention is focused upon the need for biomarker research in the interest of improving control of HNPCC." @default.
- W1569141172 created "2016-06-24" @default.
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- W1569141172 date "1991-06-01" @default.
- W1569141172 modified "2023-10-18" @default.
- W1569141172 title "Hereditary nonpolyposis colorectal cancer (Lynch syndromes I & II)" @default.
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- W1569141172 doi "https://doi.org/10.1016/0165-4608(91)90093-a" @default.
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