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- W1569152273 abstract "Considerable evidence has accumulated for a biological component to suicide risk, and preliminary work suggest that the focus of the biological abnormality may lie within the serotonin projections to the prefrontal cortex. There are early suggestions that similar factors may operate in adolescent suicides and suicide attempters. The efficacy of antidepressant medication in preventing suicidal acts in depressed patients has not yet been clearly demonstrated, although early evidence suggests that selective serotonin reuptake inhibitors may have an antisuicide component in addition to their antidepressant effects. Much research remains to be done to understand the neurochemical basis underlying restraint from suicidal ideas (threshold) during depression and other major stressors (trigger). The development of more specific treatments targetting (a) a biological elevation in the suicide threshold and (b) an early and reduced impact of triggers for suicidal acts may significantly reduce morbidity and mortality from suicidal behavior." @default.
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- W1569152273 date "2000-01-01" @default.
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- W1569152273 title "Chapter 10 Psychobiology of suicidal behavior" @default.
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