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- W1569152793 abstract "Highly purified, large molecular weight fractions of Na-hyaluronate (Healon) dissolved in physiological buffer solution in 1% concentration form viscous pastes. When 1 ml of this paste was implanted into the vitreous space of 82 owl monkey (Aotus trivirgatus) eyes, no pathological changes could be observed months or years (up to 9 years) after implantation. Implantations were made as many as seven times into the same eye without observable pathological changes in the eye. Subcortical lenticular opacities occurred in 4% of all implantations and pigmented chorioretinal lesions occurred in 8% of all implantations. The chorioretinal lesions developed in some cases after injection of balanced salt solution (BSS). This pathology was studied with electronmicroscopy. No correlation could be found between the Na-hyaluronate implantation and the development of these lesions. This pathology is believed to be caused by the surgical trauma during the exchange of half of the total volume of the liquid vitreus with balanced salt solution. During this process a mechanical dislocation between the retinal pigment epithelium and the neuroretina can occur which triggers pigment cell proliferation and subsequent pathological changes. No evidence was found of any immunogenic reaction caused by the implantation of Na-hyaluronate. The increase in vitreous protein resulting from implantation of Na-HA was three times that found after implantation of either BSS or Healon. Neither Healon nor Na-HA caused significant changes in IOP." @default.
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- W1569152793 date "1980-07-01" @default.
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- W1569152793 title "Replacement of the liquid vitreus with sodium hyaluronate in monkeys" @default.
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- W1569152793 doi "https://doi.org/10.1016/0014-4835(80)90093-7" @default.
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