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- W1569168274 abstract "In the intestine 1,25-dihydroxyvitamin D3 [1,25(OH)2D] induces various aspects of the transcellular active calcium transport system including calbindin, the basolateral plasma membrane pump, and the epithelial calcium channel, TRPV6. Calcium can enter the enterocyte through the epithelial calcium channel and then bind to calbindin and move through the cytosol. At the basolateral membrane calcium is transported actively by the plasma membrane calcium pump into the extracellular space. There is increasing evidence that, in the intestine, 1,25(OH)2D can also enhance paracellular calcium diffusion. In the distal nephron of the kidney 1,25(OH)2D induces TRPV5 and the calbindins and affects calcium transport, at least in part, by enhancing the action of PTH. A role for the Na+/Ca2+ exchanger in the distal tubule in vitamin D-dependent calcium reabsorption has also been suggested. In the kidney, besides enhancement of calcium transport in the distal nephron, 1,25(OH)2D also modulates the 25(OH)D hydroxylases. Effects on renal phosphate reabsorption have also been suggested." @default.
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- W1569168274 date "2010-01-01" @default.
- W1569168274 modified "2023-09-25" @default.
- W1569168274 title "Mechanism of Action of 1,25-Dihydroxyvitamin D3 on Intestinal Calcium Absorption and Renal Calcium Transport" @default.
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- W1569168274 doi "https://doi.org/10.1007/978-1-60327-303-9_7" @default.
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