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- W156916980 endingPage "23" @default.
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- W156916980 abstract "In the last 15 years a new class of pharmacologic agents has emerged—luteinizing hormone-releasing hormone (LHRH) analogues. As their name suggests, they are modified versions of LHRH and can either have agonistic or antagonistic properties. Because LHRH is essential for normal reproductive functions in mammals, it is not surprising that the availability of these drugs has generated much excitement, and they are currently under examination as clinical agents in such diverse areas as the augmentation of fertility [1], contraception [2], and oncology [3,4]. Our own interest in LHRH analogues began in 1977 following an approach by ICI Pharmaceuticals division in the United Kingdom to screen a series of LHRH agonists that they believed might have interesting endocrinologic and antitumor properties. The results obtained at that time clearly showed that in female rats the compounds were able to suppress ovarian activity, reduce circulating levels of estradiol, and cause a decrease in size of estrogen target tissue [5], including an ability to promote extensive regressions in estrogen receptor-positive, dimethylben-zanthracene-induced mammary tumours [6, 7]. Similarly, in male animals, LHRH agonists decreased circulating levels of testosterone and, at least in young animals, promoted an atrophy of the accessory sex organs [8–10]." @default.
- W156916980 created "2016-06-24" @default.
- W156916980 creator A5029966106 @default.
- W156916980 creator A5083774487 @default.
- W156916980 date "1988-01-01" @default.
- W156916980 modified "2023-09-26" @default.
- W156916980 title "Preclinical Studies and Antitumor Mechanism of Action of LHRH Analogues" @default.
- W156916980 cites W14279724 @default.
- W156916980 cites W1541886985 @default.
- W156916980 cites W1786463998 @default.
- W156916980 cites W1832614957 @default.
- W156916980 cites W1963501753 @default.
- W156916980 cites W1964383108 @default.
- W156916980 cites W1967012029 @default.
- W156916980 cites W1968392281 @default.
- W156916980 cites W1970624436 @default.
- W156916980 cites W1972696758 @default.
- W156916980 cites W1974020982 @default.
- W156916980 cites W1974368836 @default.
- W156916980 cites W1975035830 @default.
- W156916980 cites W1980203317 @default.
- W156916980 cites W1981956956 @default.
- W156916980 cites W1984475223 @default.
- W156916980 cites W1989313073 @default.
- W156916980 cites W1989702431 @default.
- W156916980 cites W1991618721 @default.
- W156916980 cites W1993485150 @default.
- W156916980 cites W1993886776 @default.
- W156916980 cites W1993910054 @default.
- W156916980 cites W1996252884 @default.
- W156916980 cites W1998285642 @default.
- W156916980 cites W2000301003 @default.
- W156916980 cites W2001035380 @default.
- W156916980 cites W2001758503 @default.
- W156916980 cites W2002242830 @default.
- W156916980 cites W2005066622 @default.
- W156916980 cites W2005661215 @default.
- W156916980 cites W2006732320 @default.
- W156916980 cites W2011695495 @default.
- W156916980 cites W2011718334 @default.
- W156916980 cites W2016065996 @default.
- W156916980 cites W2016520112 @default.
- W156916980 cites W2016794614 @default.
- W156916980 cites W2017072732 @default.
- W156916980 cites W2019922689 @default.
- W156916980 cites W2022590522 @default.
- W156916980 cites W2023965752 @default.
- W156916980 cites W2026853181 @default.
- W156916980 cites W2027002360 @default.
- W156916980 cites W2028328304 @default.
- W156916980 cites W2029200805 @default.
- W156916980 cites W2029842855 @default.
- W156916980 cites W2030538972 @default.
- W156916980 cites W2034271481 @default.
- W156916980 cites W2034342078 @default.
- W156916980 cites W2034512698 @default.
- W156916980 cites W2034704983 @default.
- W156916980 cites W2038356041 @default.
- W156916980 cites W2039343438 @default.
- W156916980 cites W2039865498 @default.
- W156916980 cites W2040429864 @default.
- W156916980 cites W2040446342 @default.
- W156916980 cites W2040972518 @default.
- W156916980 cites W2041268248 @default.
- W156916980 cites W2042415727 @default.
- W156916980 cites W2047108779 @default.
- W156916980 cites W2047741645 @default.
- W156916980 cites W2049947649 @default.
- W156916980 cites W2051248458 @default.
- W156916980 cites W2056059392 @default.
- W156916980 cites W2057235836 @default.
- W156916980 cites W2058590901 @default.
- W156916980 cites W2060216926 @default.
- W156916980 cites W2062988049 @default.
- W156916980 cites W2067808043 @default.
- W156916980 cites W2070864978 @default.
- W156916980 cites W2071967854 @default.
- W156916980 cites W2073111106 @default.
- W156916980 cites W2074185602 @default.
- W156916980 cites W2074425921 @default.
- W156916980 cites W2075439932 @default.
- W156916980 cites W2075492240 @default.
- W156916980 cites W2076457977 @default.
- W156916980 cites W2078908936 @default.
- W156916980 cites W2079697432 @default.
- W156916980 cites W2080751157 @default.
- W156916980 cites W2080810410 @default.
- W156916980 cites W2081715284 @default.
- W156916980 cites W2084296217 @default.
- W156916980 cites W2085645222 @default.
- W156916980 cites W2085957941 @default.
- W156916980 cites W2088910390 @default.
- W156916980 cites W2092235725 @default.
- W156916980 cites W2096750882 @default.
- W156916980 cites W2101301511 @default.
- W156916980 cites W2112835642 @default.
- W156916980 cites W2115898727 @default.
- W156916980 cites W2135456085 @default.