Matches in SemOpenAlex for { <https://semopenalex.org/work/W1569171229> ?p ?o ?g. }
- W1569171229 endingPage "1360" @default.
- W1569171229 startingPage "1348" @default.
- W1569171229 abstract "The acute hippocampal slice preparation is a convenient, in vitro model widely used to study the biological basis of synaptic plasticity. Although slices may preserve their electrophysiological properties for several hours, profound molecular changes in response to the injury caused by the slicing procedure are likely to occur. To determine the magnitude and duration of these changes we examined the post-slicing expression kinetics of three classes of genes known to be implicated in long-term synaptic plasticity: glutamate AMPA receptors (GluR), transcription factors and neurotrophins. Slicing resulted in a striking loss of GluR1 and GluR3, but not of GluR2 proteins suggesting that rapid changes in the composition of major neurotransmitter receptors may occur. Slicing caused a significant induction of the transcription factors c-fos, zif268, CCAAT enhancer binding protein (C/EBP ) beta and delta mRNAs and of the neurotrophin brain-derived neurothophic factor (BDNF ) mRNA. In contrast, there was no augmentation, and sometimes a decline, in the levels of the corresponding proteins. These data reveal that significant discrepancies exist between the slice preparation and the intact hippocampus in terms of the metabolism of molecular components known to be involved in synaptic plasticity." @default.
- W1569171229 created "2016-06-24" @default.
- W1569171229 creator A5008025407 @default.
- W1569171229 creator A5031545327 @default.
- W1569171229 creator A5062234402 @default.
- W1569171229 creator A5078608878 @default.
- W1569171229 creator A5084926216 @default.
- W1569171229 date "2002-06-06" @default.
- W1569171229 modified "2023-10-16" @default.
- W1569171229 title "Profound molecular changes following hippocampal slice preparation: loss of AMPA receptor subunits and uncoupled mRNA/protein expression" @default.
- W1569171229 cites W1032278008 @default.
- W1569171229 cites W151703357 @default.
- W1569171229 cites W1541448667 @default.
- W1569171229 cites W1562926869 @default.
- W1569171229 cites W1592924128 @default.
- W1569171229 cites W1608464482 @default.
- W1569171229 cites W1797972710 @default.
- W1569171229 cites W1863572237 @default.
- W1569171229 cites W1946757792 @default.
- W1569171229 cites W1967544492 @default.
- W1569171229 cites W1974640420 @default.
- W1569171229 cites W1990645591 @default.
- W1569171229 cites W1993565372 @default.
- W1569171229 cites W1994306864 @default.
- W1569171229 cites W1994611219 @default.
- W1569171229 cites W1995633419 @default.
- W1569171229 cites W1995954315 @default.
- W1569171229 cites W1996180957 @default.
- W1569171229 cites W1996818036 @default.
- W1569171229 cites W2000828861 @default.
- W1569171229 cites W2011965698 @default.
- W1569171229 cites W2012783173 @default.
- W1569171229 cites W2015313594 @default.
- W1569171229 cites W2017244291 @default.
- W1569171229 cites W2019080685 @default.
- W1569171229 cites W2020649652 @default.
- W1569171229 cites W2025094293 @default.
- W1569171229 cites W2025581014 @default.
- W1569171229 cites W2027877806 @default.
- W1569171229 cites W2030284957 @default.
- W1569171229 cites W2030476972 @default.
- W1569171229 cites W2032178498 @default.
- W1569171229 cites W2036686922 @default.
- W1569171229 cites W2039567064 @default.
- W1569171229 cites W2043845653 @default.
- W1569171229 cites W2044371401 @default.
- W1569171229 cites W2044992592 @default.
- W1569171229 cites W2049178206 @default.
- W1569171229 cites W2050552159 @default.
- W1569171229 cites W2055817523 @default.
- W1569171229 cites W2055829187 @default.
- W1569171229 cites W2056539638 @default.
- W1569171229 cites W2057318097 @default.
- W1569171229 cites W2063089911 @default.
- W1569171229 cites W2063440901 @default.
- W1569171229 cites W2063753940 @default.
- W1569171229 cites W2064475634 @default.
- W1569171229 cites W2066281989 @default.
- W1569171229 cites W2069548932 @default.
- W1569171229 cites W2078001244 @default.
- W1569171229 cites W2081212941 @default.
- W1569171229 cites W2084055869 @default.
- W1569171229 cites W2085431257 @default.
- W1569171229 cites W2089346216 @default.
- W1569171229 cites W2094988206 @default.
- W1569171229 cites W2095470091 @default.
- W1569171229 cites W2101177880 @default.
- W1569171229 cites W2115736681 @default.
- W1569171229 cites W2116101254 @default.
- W1569171229 cites W2122165239 @default.
- W1569171229 cites W2122835512 @default.
- W1569171229 cites W2134812217 @default.
- W1569171229 cites W2135557002 @default.
- W1569171229 cites W2136700941 @default.
- W1569171229 cites W2136761139 @default.
- W1569171229 cites W2147715586 @default.
- W1569171229 cites W2159380021 @default.
- W1569171229 cites W2160864040 @default.
- W1569171229 cites W2163163883 @default.
- W1569171229 cites W2265600915 @default.
- W1569171229 cites W2411243794 @default.
- W1569171229 cites W4236022995 @default.
- W1569171229 doi "https://doi.org/10.1046/j.1471-4159.2002.00936.x" @default.
- W1569171229 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12068082" @default.
- W1569171229 hasPublicationYear "2002" @default.
- W1569171229 type Work @default.
- W1569171229 sameAs 1569171229 @default.
- W1569171229 citedByCount "44" @default.
- W1569171229 countsByYear W15691712292013 @default.
- W1569171229 countsByYear W15691712292015 @default.
- W1569171229 countsByYear W15691712292016 @default.
- W1569171229 countsByYear W15691712292017 @default.
- W1569171229 countsByYear W15691712292018 @default.
- W1569171229 countsByYear W15691712292019 @default.
- W1569171229 countsByYear W15691712292020 @default.
- W1569171229 countsByYear W15691712292021 @default.
- W1569171229 crossrefType "journal-article" @default.
- W1569171229 hasAuthorship W1569171229A5008025407 @default.