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• W1569182826 abstract "OBJECTIVE: To compare serologic methods and detection of urinary antigen in the diagnosis of community-acquired pneumonia. METHODS: Paired sera from 84 patients with community-acquired pneumonia were tested for Legionella pneumophila serogroup (LP SG) 1-7 and Legionella micdadei by use of the indirect immunofluorescence antibody test (IIF), enzyme-linked immunosorbent assay (ELISA) for LP SG 1-7 and complement-fixation (CF) test for LP SG 1. All patients were evaluated by ELISA urinary antigen detection for LP SG 1. RESULTS: Seven patients met the CDC criteria for acute Legionella infection, while in the rest of them we failed to detect urinary Legionella antigen. Thirty-three patients had non-diagnostic IIF antibody titers. Serum ELISA (IgG and/or IgM) was positive in 40 patients. Nine patients showed at least one CF titer of >/=1:32. The sensitivities of ELISA IgM for the first and the second serum samples compared with IIF were 42.8% and 46.6%, respectively, while the specificities were higher, i.e. 87% and 88.4%, respectively. The sensitivities of ELISA IgG for the first and the second samples were 42.8% and 53.3%, and the specificities were 77.9% and 76.8%, respectively. CONCLUSIONS: Although ELISA is simple to perform and easy to automate, we think that its advantages over indirect immunofluorescence and urinary antigen detection remain questionable." @default.
• W1569182826 created "2016-06-24" @default.
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• W1569182826 date "1999-04-01" @default.
• W1569182826 modified "2023-10-18" @default.
• W1569182826 title "Comparison of serologic tests with urinary antigen detection for diagnosis of legionnaires’ disease in patients with community-acquired pneumonia" @default.
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• W1569182826 doi "https://doi.org/10.1111/j.1469-0691.1999.tb00124.x" @default.
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