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- W1569186451 abstract "Uveitis is a frequent ophthalmic disorder in the domestic cat, often associated with mortal systemic diseases of high prevalence in this species. In addition, uveitis may be caused by perforating or blunt traumas provoked by fights or car accidents. The process starts with a local lesion in the haematoocular barrier which increases the vascular permeability. The infiltrated leukocytes release cytokines and other inflammatory chemical mediators, like arachidonic acid metabolites and reactive species of oxygen (ROS). The increased amount of ROS may overpass the capacity of the endogen antioxidant system and produces an irreversible lesion in the different ocular structures. At present, the therapy against uveitis is mainly directed towards pain reduction and to avoid lesions in visual tissues. In general, it is based on the use of corticoids and no steroid antiinflammatory drugs. However, in recent studies it has been shown that only 33% of animals affected by uveitis associated to systemic diseases respond to the treatment. The aim of the present revision is to present the current status of knowledge regarding the physiopathology of uveitis and to analyze available drugs for its treatment. In addition, possible alternative therapies will be suggested." @default.
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- W1569186451 date "2005-01-01" @default.
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- W1569186451 title "Uveítis en el felino" @default.
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