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- W1569198071 abstract "Non-alcoholic fatty liver disease (NAFLD) has evolved as the most common form of chronic liver disease in children and has become a serious public health issue. As in adults, NAFLD in children is tightly associated with obesity, insulin resistance, and a number of obesity-related metabolic complications. In children, the disease is mostly silent and often discovered through incidentally elevated liver enzyme levels or abnormal findings on ultrasound. The precise determination of the severity of the disease requires a liver biopsy with histological evaluation. The full spectrum of the disease from isolated hepatic steatosis to non-alcoholic steatohepatitis (NASH) to cirrhosis has been described in children, and the individual histological features may show a distinct pattern from that in adults. While the natural history of the disease diagnosed during childhood remains incompletely defined, growing evidence suggests that children with NAFLD are at increased risk of metabolic complications, while those with NASH and advanced fibrosis are also at risk of significant liver-related morbidity; the latter may require liver transplantation during late adolescence or early adulthood. Recent advances in the development of non-invasive diagnostic tools and therapeutics may result in the near future in significant changes in the management of this condition in children." @default.
- W1569198071 created "2016-06-24" @default.
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- W1569198071 date "2013-03-08" @default.
- W1569198071 modified "2023-10-18" @default.
- W1569198071 title "NAFLD in Children" @default.
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- W1569198071 doi "https://doi.org/10.1002/9781118556153.ch15" @default.
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