Matches in SemOpenAlex for { <https://semopenalex.org/work/W1569214791> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W1569214791 endingPage "115.15" @default.
- W1569214791 startingPage "115.15" @default.
- W1569214791 abstract "Abstract We recently reported a method for amplifying paired T cell receptor (TCR) αβ CDR3 regions from single cells in mice and have developed a similar protocol for human cells. Using this technique, we have discovered a surprising plasticity in peripheral TCR repertoire, particularly under conditions of inflammation. This plasticity includes two major mechanisms: TCR modulation and TCR revision. Modulation consists of the up or down regulation of secondary allele expression, almost exclusively from the TCRα locus. Revision results in changes to the amino acid sequence of the TCR by de novo rearrangement. Here we describe the upregulation of both processes in CD8+ T cells derived from influenza-infected lungs when compared to circulating naïve T cells. In particular, instances of modulation and dual chain expression are elevated over the course of a primary influenza T cell response, whereas in recall responses memory cells express only a single allele of each TCR chain. In repeated infections, revised TCRs are observed by using out of frame TCR sequences as an internal, lineage specific, barcode. The relative contribution of each mechanism to the activation of autoreactive T cells is assessed in genetic models." @default.
- W1569214791 created "2016-06-24" @default.
- W1569214791 creator A5035851025 @default.
- W1569214791 creator A5071766732 @default.
- W1569214791 creator A5090006268 @default.
- W1569214791 date "2012-05-01" @default.
- W1569214791 modified "2023-10-16" @default.
- W1569214791 title "Mechanisms of plasticity in the peripheral T cell receptor repertoire (115.15)" @default.
- W1569214791 doi "https://doi.org/10.4049/jimmunol.188.supp.115.15" @default.
- W1569214791 hasPublicationYear "2012" @default.
- W1569214791 type Work @default.
- W1569214791 sameAs 1569214791 @default.
- W1569214791 citedByCount "0" @default.
- W1569214791 crossrefType "journal-article" @default.
- W1569214791 hasAuthorship W1569214791A5035851025 @default.
- W1569214791 hasAuthorship W1569214791A5071766732 @default.
- W1569214791 hasAuthorship W1569214791A5090006268 @default.
- W1569214791 hasConcept C104317684 @default.
- W1569214791 hasConcept C121332964 @default.
- W1569214791 hasConcept C127561419 @default.
- W1569214791 hasConcept C147483822 @default.
- W1569214791 hasConcept C153911025 @default.
- W1569214791 hasConcept C167672396 @default.
- W1569214791 hasConcept C170493617 @default.
- W1569214791 hasConcept C19317047 @default.
- W1569214791 hasConcept C203014093 @default.
- W1569214791 hasConcept C24890656 @default.
- W1569214791 hasConcept C2776090121 @default.
- W1569214791 hasConcept C2778473898 @default.
- W1569214791 hasConcept C54355233 @default.
- W1569214791 hasConcept C84597430 @default.
- W1569214791 hasConcept C86803240 @default.
- W1569214791 hasConcept C8891405 @default.
- W1569214791 hasConcept C95444343 @default.
- W1569214791 hasConceptScore W1569214791C104317684 @default.
- W1569214791 hasConceptScore W1569214791C121332964 @default.
- W1569214791 hasConceptScore W1569214791C127561419 @default.
- W1569214791 hasConceptScore W1569214791C147483822 @default.
- W1569214791 hasConceptScore W1569214791C153911025 @default.
- W1569214791 hasConceptScore W1569214791C167672396 @default.
- W1569214791 hasConceptScore W1569214791C170493617 @default.
- W1569214791 hasConceptScore W1569214791C19317047 @default.
- W1569214791 hasConceptScore W1569214791C203014093 @default.
- W1569214791 hasConceptScore W1569214791C24890656 @default.
- W1569214791 hasConceptScore W1569214791C2776090121 @default.
- W1569214791 hasConceptScore W1569214791C2778473898 @default.
- W1569214791 hasConceptScore W1569214791C54355233 @default.
- W1569214791 hasConceptScore W1569214791C84597430 @default.
- W1569214791 hasConceptScore W1569214791C86803240 @default.
- W1569214791 hasConceptScore W1569214791C8891405 @default.
- W1569214791 hasConceptScore W1569214791C95444343 @default.
- W1569214791 hasIssue "1_Supplement" @default.
- W1569214791 hasLocation W15692147911 @default.
- W1569214791 hasOpenAccess W1569214791 @default.
- W1569214791 hasPrimaryLocation W15692147911 @default.
- W1569214791 hasRelatedWork W1487389411 @default.
- W1569214791 hasRelatedWork W1851979138 @default.
- W1569214791 hasRelatedWork W2024351954 @default.
- W1569214791 hasRelatedWork W2057739827 @default.
- W1569214791 hasRelatedWork W2070745303 @default.
- W1569214791 hasRelatedWork W2078108429 @default.
- W1569214791 hasRelatedWork W2139229993 @default.
- W1569214791 hasRelatedWork W4313380718 @default.
- W1569214791 hasRelatedWork W4319433400 @default.
- W1569214791 hasRelatedWork W4362546279 @default.
- W1569214791 hasVolume "188" @default.
- W1569214791 isParatext "false" @default.
- W1569214791 isRetracted "false" @default.
- W1569214791 magId "1569214791" @default.
- W1569214791 workType "article" @default.