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- W1569217300 abstract "Immunotherapies, as a promising anticancer therapy stratrgy, has been paid more and more attentions. However, the abnormal tumor vasculature creates a hypoxic microenvironment that make immune cells toward immune suppression. The immunosuppressive microenvironment seems to impede the development of immunotherapies. Hence, normalization tumor vascular by anti-angiogenesis properly could improve the immunosuppressive miroenvironment. Consequently, the efficacy of the immunotherapies was enhanced. Here, we discuss the effects of vascular normalizing on tumor immunity and propose a potentially strategy to re-engineer the tumor-immune microenvironment and improve cancer immunotherapy. 免疫治疗是一种颇有前景的抗肿瘤策略。然而，肿瘤中的免疫抑制微环境阻碍了免疫治疗的发展。异常肿瘤血管造成的缺氧，使免疫细胞趋向免疫抑制。并且异常血管通过分泌生长因子及细胞因子，改变免疫细胞的增殖、分化及功能，最终形成免疫抑制的微环境。因此，有效的利用血管生成及肿瘤免疫之间的相互作用，适当的抑制血管形成，促进肿瘤血管正常化，可以改变肿瘤的免疫抑制微环境，成为改善免疫治疗的新策略。现就血管正常化与肿瘤免疫的关系，及二者的联合治疗进行综述。。" @default.
- W1569217300 created "2016-06-24" @default.
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- W1569217300 date "2014-03-01" @default.
- W1569217300 modified "2023-09-23" @default.
- W1569217300 title "[Vascular normalization and cancer immunotherapy]." @default.
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- W1569217300 doi "https://doi.org/10.3779/j.issn.1009-3419.2014.03.16" @default.
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