FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1569221250> ?p ?o ?g. }

• W1569221250 endingPage "519" @default.
• W1569221250 startingPage "506" @default.
• W1569221250 abstract "The fungal cell wall, a conserved and highly dynamic structure, is essential for virulence and viability of fungal pathogens and is an important antifungal drug target. The cell wall integrity (CWI) signalling pathway regulates shape and biosynthesis of the cell wall. In this work we identified, localized and functionally characterized four putative CWI stress sensors of Aspergillus fumigatus, an airborne opportunistic human pathogen and the cause of invasive aspergillosis. We show that Wsc1 is specifically required for resistance to echinocandin antifungals. MidA is specifically required for elevated temperature tolerance and resistance to the cell wall perturbing agents congo red and calcofluor white. Wsc1, Wsc3 and MidA additionally have overlapping functions and are redundantly required for radial growth and conidiation. We have also analysed the roles of three Rho GTPases that have been implicated in CWI signalling in other fungi. We show that Rho1 is essential and that conditional downregulation of rho1 or deletion of rho2 or rho4 results in severely impaired CWI. Our data indicate significant functional differences between the CWI stress sensors of yeasts and moulds." @default.
• W1569221250 created "2016-06-24" @default.
• W1569221250 creator A5000829320 @default.
• W1569221250 creator A5027328055 @default.
• W1569221250 creator A5050537287 @default.
• W1569221250 creator A5050587590 @default.
• W1569221250 date "2012-01-04" @default.
• W1569221250 modified "2023-10-16" @default.
• W1569221250 title "Deciphering cell wall integrity signalling in Aspergillus fumigatus: identification and functional characterization of cell wall stress sensors and relevant Rho GTPases" @default.
• W1569221250 cites W11988849 @default.
• W1569221250 cites W1485925377 @default.
• W1569221250 cites W1563122875 @default.
• W1569221250 cites W1789911598 @default.
• W1569221250 cites W1970525414 @default.
• W1569221250 cites W1987755757 @default.
• W1569221250 cites W1993668738 @default.
• W1569221250 cites W2007653122 @default.
• W1569221250 cites W2021774175 @default.
• W1569221250 cites W2022366078 @default.
• W1569221250 cites W2053566107 @default.
• W1569221250 cites W2061879227 @default.
• W1569221250 cites W2068535614 @default.
• W1569221250 cites W2068867976 @default.
• W1569221250 cites W2088462705 @default.
• W1569221250 cites W2096833920 @default.
• W1569221250 cites W2101667055 @default.
• W1569221250 cites W2106031809 @default.
• W1569221250 cites W2118657913 @default.
• W1569221250 cites W2121101355 @default.
• W1569221250 cites W2123150152 @default.
• W1569221250 cites W2128025573 @default.
• W1569221250 cites W2138136834 @default.
• W1569221250 cites W2138253605 @default.
• W1569221250 cites W2152482941 @default.
• W1569221250 cites W2157937554 @default.
• W1569221250 cites W2159072518 @default.
• W1569221250 cites W2593716255 @default.
• W1569221250 cites W4210623056 @default.
• W1569221250 doi "https://doi.org/10.1111/j.1365-2958.2011.07946.x" @default.
• W1569221250 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22220813" @default.
• W1569221250 hasPublicationYear "2012" @default.
• W1569221250 type Work @default.
• W1569221250 sameAs 1569221250 @default.
• W1569221250 citedByCount "102" @default.
• W1569221250 countsByYear W15692212502012 @default.
• W1569221250 countsByYear W15692212502013 @default.
• W1569221250 countsByYear W15692212502014 @default.
• W1569221250 countsByYear W15692212502015 @default.
• W1569221250 countsByYear W15692212502016 @default.
• W1569221250 countsByYear W15692212502017 @default.
• W1569221250 countsByYear W15692212502018 @default.
• W1569221250 countsByYear W15692212502019 @default.
• W1569221250 countsByYear W15692212502020 @default.
• W1569221250 countsByYear W15692212502021 @default.
• W1569221250 countsByYear W15692212502022 @default.
• W1569221250 countsByYear W15692212502023 @default.
• W1569221250 crossrefType "journal-article" @default.
• W1569221250 hasAuthorship W1569221250A5000829320 @default.
• W1569221250 hasAuthorship W1569221250A5027328055 @default.
• W1569221250 hasAuthorship W1569221250A5050537287 @default.
• W1569221250 hasAuthorship W1569221250A5050587590 @default.
• W1569221250 hasBestOaLocation W15692212501 @default.
• W1569221250 hasConcept C104317684 @default.
• W1569221250 hasConcept C125235067 @default.
• W1569221250 hasConcept C127561419 @default.
• W1569221250 hasConcept C207332259 @default.
• W1569221250 hasConcept C2779347548 @default.
• W1569221250 hasConcept C2779787849 @default.
• W1569221250 hasConcept C55493867 @default.
• W1569221250 hasConcept C60987743 @default.
• W1569221250 hasConcept C86803240 @default.
• W1569221250 hasConcept C89423630 @default.
• W1569221250 hasConcept C95444343 @default.
• W1569221250 hasConceptScore W1569221250C104317684 @default.
• W1569221250 hasConceptScore W1569221250C125235067 @default.
• W1569221250 hasConceptScore W1569221250C127561419 @default.
• W1569221250 hasConceptScore W1569221250C207332259 @default.
• W1569221250 hasConceptScore W1569221250C2779347548 @default.
• W1569221250 hasConceptScore W1569221250C2779787849 @default.
• W1569221250 hasConceptScore W1569221250C55493867 @default.
• W1569221250 hasConceptScore W1569221250C60987743 @default.
• W1569221250 hasConceptScore W1569221250C86803240 @default.
• W1569221250 hasConceptScore W1569221250C89423630 @default.
• W1569221250 hasConceptScore W1569221250C95444343 @default.
• W1569221250 hasIssue "3" @default.
• W1569221250 hasLocation W15692212501 @default.
• W1569221250 hasLocation W15692212502 @default.
• W1569221250 hasOpenAccess W1569221250 @default.
• W1569221250 hasPrimaryLocation W15692212501 @default.
• W1569221250 hasRelatedWork W1569221250 @default.
• W1569221250 hasRelatedWork W1598333916 @default.
• W1569221250 hasRelatedWork W2008191665 @default.
• W1569221250 hasRelatedWork W2028640502 @default.
• W1569221250 hasRelatedWork W2135280679 @default.
• W1569221250 hasRelatedWork W2154914147 @default.
• W1569221250 hasRelatedWork W3005406464 @default.
• W1569221250 hasRelatedWork W3005653490 @default.
• W1569221250 hasRelatedWork W3092274602 @default.

• next