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• W1569221343 startingPage "7518" @default.
• W1569221343 abstract "Fc receptor-like 3 (FCRL3) is a cell surface protein homologous to Fc receptors. The FCRL3 gene is present in humans but not in mice. We found that FCRL3 protein is expressed on 40% of human naturally occurring CD4(+) regulatory T (nTreg) cells (CD4(+)CD25(+)CD127(low)). Sorted nTreg cells with the surface phenotype FCRL3(+) and FCRL3(-) were both hypoproliferative to TCR stimulation and both suppressive on proliferation of conventional T cells (CD4(+)CD25(-)) in vitro. They both expressed forkhead box p3 (Foxp3) protein, the intracellular regulatory T cell marker. However, in contrast to FCRL3(-) nTreg cells, FCRL3(+) nTreg cells were not stimulated to proliferate by the addition of exogenous IL-2. In addition, Foxp3(+) cells induced from conventional T cells by TGF-beta treatment did not exhibit FCRL3 expression. These results suggest that the FCRL3(+) subset of human nTreg cells identified in this study arise in vivo and Foxp3 expression alone is not sufficient to induce FCRL3 expression. FCRL3 may be involved in human-specific mechanisms to control the generation of nTreg cells." @default.
• W1569221343 created "2016-06-24" @default.
• W1569221343 creator A5025804896 @default.
• W1569221343 creator A5056573254 @default.
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• W1569221343 date "2009-06-15" @default.
• W1569221343 modified "2023-10-18" @default.
• W1569221343 title "Fc Receptor-Like 3 Protein Expressed on IL-2 Nonresponsive Subset of Human Regulatory T Cells" @default.
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• W1569221343 doi "https://doi.org/10.4049/jimmunol.0802230" @default.
• W1569221343 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2745186" @default.
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