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• W1569229589 abstract "6 LIST OF ORIGINAL PAPERS 7 LIST OF ABBREVIATIONS 8 INTRODUCTION 9 Myocardial ischaemia-reperfusion injury 9 Endothelial function 9 Nitric oxide 10 Endothelin-1 11 Endothelial dysfunction 11 HMG-Co reductase inhibitors (statins) 12 Peroxisome proliferator-activated receptors 14 14 15 15 Cardiovascular effects of PPARs 15 15 16 Cardioprotective effects of PPARs 16 AIMS 18 MATERIALS AND METHODS 19 Animal preparation 19 Pig experimental model (Study I) 19 Rat experimental model (Studies II and III) 19 Isolated mouse heart (Study IV) 20 Experimental protocols 20 Study I 20 Study II 20 Study III 21 Study IV 21 Determination of area at risk and infarct size (Studies I-III) 22 Immunoblotting (Studies I-IV) 22 Real-time reverse transcription (RT)-PCR (Study III) 23 Myeloperoxidase activity (Study I) 23 Serum cholesterol analysis (Study I) 24 Analysis of rosuvastatin plasma concentration (Study I) 24 Calculations 24 Statistical methods 24 Cardioprotection by statins and PPAR ligands 5 RESULTS 25 Effect of statins on ischaemia-reperfusion injury, MPO activity and RhoA translocation (Studies I and II) 25 involvement of NO and ET-1 (Study III) 27 involvement of NO (Study IV) 29 DISCUSSION 31 evidence for “pleiotropic” effect of statins 31 Involvement of NO and ET-1 in cardioprotective effect of 33 Methodological limitations 37 REFERENCES 41 ABSTRACT 6 Aliaksandr Bulhak6 Aliaksandr Bulhak Acute myocardial ischaemia causes metabolic changes and results in a rapid decrease in the energy available to the cell. This leads to cell injury that, depending on the length of the ischaemic time, is reversible or irreversible. Restoratissue survival, but may also per se contribute to the injury. Endothelial dysfunction, characterized by an impairment of endothelium-dependent relaxation, due to reduced bioavailability of endothelial nitric oxide (NO), is an early event in the pathophysiology of myocardial ischaemia-reperfusion injury. Endothelial dysfunction is also important in other cardiovascular disorders such as atherosclerosis, hypertension, and diabetes. It has been suggested that drugs used in the treatment of these disorders also exert cardioprotective effects. Inhibitors of 3 hydroxy-3-methylglutaryl and insulin-sensitizing effects.The aim of the present thesis was to investigate the cardioprotective mechanisms of drugs used for treatment of hyperlipidaemia and insulin resistance. Of particular interest was to study the mechanisms related to NO bioavailability. 1. Oral pretreatment with the HMG-CoA reductase inhibitors rosuvastatin and pravastatin for 5 days, without affecting serum cholesterol, reduced infarct size (IS) in pigs subjected to 45 min of ischaemia followed by" @default.
• W1569229589 created "2016-06-24" @default.
• W1569229589 creator A5077257028 @default.
• W1569229589 date "2007-05-25" @default.
• W1569229589 modified "2023-09-27" @default.
• W1569229589 title "Cardioprotective mechanisms by inhibition of the HMG-CoA reductase pathway and stimulation of peroxisome proliferator-activated receptors in myocardial ischaemia-reperfusion" @default.
• W1569229589 cites W121348928 @default.
• W1569229589 cites W1479880028 @default.
• W1569229589 cites W1525482898 @default.
• W1569229589 cites W1567127662 @default.
• W1569229589 cites W1577454575 @default.
• W1569229589 cites W1607892649 @default.
• W1569229589 cites W1633340712 @default.
• W1569229589 cites W1851149345 @default.
• W1569229589 cites W1929009802 @default.
• W1569229589 cites W1964010585 @default.
• W1569229589 cites W1965745612 @default.
• W1569229589 cites W1968873332 @default.
• W1569229589 cites W1970583496 @default.
• W1569229589 cites W1980358798 @default.
• W1569229589 cites W1982572128 @default.
• W1569229589 cites W1986273912 @default.
• W1569229589 cites W1989070839 @default.
• W1569229589 cites W1990779251 @default.
• W1569229589 cites W1991583073 @default.
• W1569229589 cites W1999742888 @default.
• W1569229589 cites W2005515164 @default.
• W1569229589 cites W2008048680 @default.
• W1569229589 cites W2008589779 @default.
• W1569229589 cites W2010092661 @default.
• W1569229589 cites W2012457700 @default.
• W1569229589 cites W2012834939 @default.
• W1569229589 cites W2014237668 @default.
• W1569229589 cites W2014434817 @default.
• W1569229589 cites W2018032623 @default.
• W1569229589 cites W2019235722 @default.
• W1569229589 cites W2021823569 @default.
• W1569229589 cites W2022353607 @default.
• W1569229589 cites W2024556437 @default.
• W1569229589 cites W2028305848 @default.
• W1569229589 cites W2029491963 @default.
• W1569229589 cites W2032203291 @default.
• W1569229589 cites W2033204507 @default.
• W1569229589 cites W2034321283 @default.
• W1569229589 cites W2036787121 @default.
• W1569229589 cites W2038654926 @default.
• W1569229589 cites W2040200395 @default.
• W1569229589 cites W2041075406 @default.
• W1569229589 cites W2042006175 @default.
• W1569229589 cites W2042928998 @default.
• W1569229589 cites W2045126498 @default.
• W1569229589 cites W2045497589 @default.
• W1569229589 cites W2048635427 @default.
• W1569229589 cites W2050548878 @default.
• W1569229589 cites W2054727930 @default.
• W1569229589 cites W2058137293 @default.
• W1569229589 cites W2059232148 @default.
• W1569229589 cites W2059906195 @default.
• W1569229589 cites W2066092624 @default.
• W1569229589 cites W2067236087 @default.
• W1569229589 cites W2068820862 @default.
• W1569229589 cites W2069600859 @default.
• W1569229589 cites W2072405519 @default.
• W1569229589 cites W2074858413 @default.
• W1569229589 cites W2075385622 @default.
• W1569229589 cites W2076769000 @default.
• W1569229589 cites W2079949565 @default.
• W1569229589 cites W2080045599 @default.
• W1569229589 cites W2080085786 @default.
• W1569229589 cites W2080453664 @default.
• W1569229589 cites W2080590768 @default.
• W1569229589 cites W2089308595 @default.
• W1569229589 cites W2090688283 @default.
• W1569229589 cites W2092145002 @default.
• W1569229589 cites W2097435560 @default.
• W1569229589 cites W2098132645 @default.
• W1569229589 cites W2098946775 @default.
• W1569229589 cites W2100926526 @default.
• W1569229589 cites W2102469433 @default.
• W1569229589 cites W2103349348 @default.
• W1569229589 cites W2107326660 @default.
• W1569229589 cites W2108116605 @default.
• W1569229589 cites W2115154703 @default.
• W1569229589 cites W2115830594 @default.
• W1569229589 cites W2116672342 @default.
• W1569229589 cites W2119617266 @default.
• W1569229589 cites W2122083337 @default.
• W1569229589 cites W2123404136 @default.
• W1569229589 cites W2126534770 @default.
• W1569229589 cites W2127708948 @default.
• W1569229589 cites W2130054105 @default.
• W1569229589 cites W2130487566 @default.
• W1569229589 cites W2132659447 @default.
• W1569229589 cites W2135801405 @default.
• W1569229589 cites W2138220081 @default.
• W1569229589 cites W2139473713 @default.
• W1569229589 cites W2140527220 @default.
• W1569229589 cites W2141501498 @default.
• W1569229589 cites W2142313665 @default.
• W1569229589 cites W2142471538 @default.

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