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- W1569243743 abstract "The diffusion and transport of neurotransmitter molecules occurs on a time scale of microseconds to milliseconds, and over a length scale of nanometers to microns. These dimensions preclude direct measurement of the spatiotemporal profile of transmitter in the immediate vicinity of the synaptic cleft by conventional means. However, it is possible to use the synaptic receptor/ion channels themselves as local sensors for the transmitter. Here, we describe experimental measurements of the concentration and time course of GABA in the synaptic cleft, and use the values obtained to constrain a quantitative model of GABA diffusion, uptake and crosstalk between synapses." @default.
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- W1569243743 date "2002-08-23" @default.
- W1569243743 modified "2023-09-26" @default.
- W1569243743 title "Measuring and Modeling the Spatiotemporal Profile of GABA at the Synapse" @default.
- W1569243743 doi "https://doi.org/10.1002/0471434043.ch16" @default.
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