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• W1569244522 abstract "To the Editor: We read the prospective observational study by Kuragano et al.1.Kuragano T. Matsumura O. Matsuda A. et al.Association between hemoglobin variability, serum ferritin levels, and adverse events/mortality in maintenance hemodialysis patients.Kidney Int. 2014; 86: 845-854Abstract Full Text Full Text PDF PubMed Scopus (118) Google Scholar In the article, the authors use a standard serum ferritin level of 100 ng/ml to analyze the effects of ferritin. Ferritin measurement methods generally vary widely among measurement methods. Caution is necessary when making clinical decisions for dialysis patients as well, for whom the use of a single measurement is not recommended.2.Ford B.A. Coyne D.W. Eby C.S. et al.Variability of ferritin measurements in chronic kidney disease; implications for iron management.Kidney Int. 2009; 75: 104-110Abstract Full Text Full Text PDF PubMed Scopus (50) Google Scholar In addition, at least five measurement methods for serum ferritin and at least 30 assay kits are available in Japan today. The coefficient of variation among ferritin measurement methods in Japan was from 14.0 to 17.1% in 2008,3Subcommittee for Radioisotope in vitro Test, Medical Science and Pharmaceutical Committee, Japan Radioisotope Association Immunoassay Research Society of Japan (Japan Radioisotope Association). A summary report on the 30th quality control survey for immunoassays in Japan, 2008.Radioisotopes. 2009; 58 ([article in Japanese]): 655-708Crossref Google Scholar and from 16.55 to 18.03% even today.4Present Situation and Issues of Japan Medical Association External Quality Control Program 47. Japan Medical Association.: Tokyo, 2014 [in Japanese].Google Scholar In short, measurements of a given sample could be as disparate as measurement levels of 100 and 200 ng/ml, depending on kits. At a low standard serum ferritin level such as 100 ng/ml, the measurement variability becomes clinically relevant, having a large impact on the difference between doses of iron given at different facilities. Multifacility observational studies need a standardized measurement method and assay kit. What rules did the authors have for ferritin assays and how did the authors correct for variability among assay kits? Finally, the authors list ‘Doses of erythropoietin and iron requiring for the maintenance of Hb level >11 g/dl’ as a primary outcome in the clinical trial registration UMIN000000687 entry, but ‘Doses of erythropoietin and iron requiring for the maintenance of Hb level of 10–11 g/dl’ in the article. Did the authors change this primary outcome during the study?" @default.
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• W1569244522 date "2015-07-01" @default.
• W1569244522 modified "2023-10-02" @default.
• W1569244522 title "Coefficient of variation among ferritin measurement methods in hemodialysis and standard serum ferritin level" @default.
• W1569244522 cites W2017642851 @default.
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• W1569244522 doi "https://doi.org/10.1038/ki.2015.126" @default.
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