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- W1569249852 abstract "Failure of germ cell development is associated with complete ovarian failure, resulting in lack of secondary sexual pubertal development (primary amenorrhea). A decreased number but not a total absence of germ cells is more likely associated with premature ovarian failure, presenting with infertility or secondary amenorrhea. Yet complete and premature ovarian failure may be different manifestations of the same underlying pathogenic and etiologic processes. Many different genetic mechanisms are pertinent to the processes m chromosomal abnormalities, Mendelian mutations of autosomal or X-linked genes, and polygenic/multifactorial factors. In the absence of the Y chromosome, the indifferent embryonic gonad always develops into an ovary. Germ cells exist in 45,X human fetuses. Oocyte development initially exists even in 46,XY phenotypic females, such as in infants with XY gonadal dysgenesis or the genito-palatocardiac syndrome. Oocyte development in the presence of a Y chromosome is also well documented in mice. Thus, the pathogenesis of germ cell failure in humans can be deduced to be increased germ cell attrition. If two intact X chromosomes are not present, ovarian follicles in 45,X individuals usually degenerate by birth." @default.
- W1569249852 created "2016-06-24" @default.
- W1569249852 creator A5080697469 @default.
- W1569249852 date "2000-01-01" @default.
- W1569249852 modified "2023-09-25" @default.
- W1569249852 title "Genetic Programming in Ovarian Development and Oogenesis" @default.
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- W1569249852 doi "https://doi.org/10.1016/b978-012453790-3/50006-8" @default.
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