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- W1569251007 abstract "This chapter presents evidence that calpain over activation may be a key component in a number of disorders. The common theme for most of these disorders is cellular Ca2+ overload. The calpains can be found in the cytosolic compartment and can also be identified in the plasma membrane and other organelle membranes. Both isoforms contain two subunits. Calpain appears to be an ideal pharmaceutical target, as this protease is most active during pathological events. The current challenge is to identify cell-permeable and selective calpain inhibitors for evaluation in various in vivo disease models. As the knowledge of calpain substrate specificity is increasing and calpain inhibitors from natural products screening programs are becoming available, more selective inhibitors are designed and synthesized. At present there is an arsenal of calpain inhibitors for disposal. These inhibitors include protein inhibitors, such as calpastatin, irreversible peptide inhibitors, such as E64 analogs, reversible peptide inhibitors, such as peptidyl α-keto amides, and several nonpeptide inhibitors. With the recent emergence of several cell-permeable calpain selective inhibitors, the goal of understanding the physiological roles of calpain are possible to be achievable." @default.
- W1569251007 created "2016-06-24" @default.
- W1569251007 creator A5059902188 @default.
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- W1569251007 date "1996-01-01" @default.
- W1569251007 modified "2023-09-27" @default.
- W1569251007 title "Development and Therapeutic Potential of Calpain Inhibitors" @default.
- W1569251007 cites W135737008 @default.
- W1569251007 cites W1493954404 @default.
- W1569251007 cites W1494073567 @default.
- W1569251007 cites W1523373796 @default.
- W1569251007 cites W152388943 @default.
- W1569251007 cites W1528365264 @default.
- W1569251007 cites W1530246363 @default.
- W1569251007 cites W1532539996 @default.
- W1569251007 cites W1556189642 @default.
- W1569251007 cites W1571628730 @default.
- W1569251007 cites W1572398159 @default.
- W1569251007 cites W1574047547 @default.
- W1569251007 cites W1578058970 @default.
- W1569251007 cites W1579053513 @default.
- W1569251007 cites W1602061583 @default.
- W1569251007 cites W1622269784 @default.
- W1569251007 cites W1639940444 @default.
- W1569251007 cites W1730185705 @default.
- W1569251007 cites W1812339273 @default.
- W1569251007 cites W1831777278 @default.
- W1569251007 cites W1837500998 @default.
- W1569251007 cites W1846089783 @default.
- W1569251007 cites W1859261521 @default.
- W1569251007 cites W1865614480 @default.
- W1569251007 cites W1938761694 @default.
- W1569251007 cites W1957958801 @default.
- W1569251007 cites W1963697102 @default.
- W1569251007 cites W1965882103 @default.
- W1569251007 cites W1967331491 @default.
- W1569251007 cites W1967848085 @default.
- W1569251007 cites W1969865757 @default.
- W1569251007 cites W1969871756 @default.
- W1569251007 cites W1970426196 @default.
- W1569251007 cites W1971010898 @default.
- W1569251007 cites W1974315144 @default.
- W1569251007 cites W1977370691 @default.
- W1569251007 cites W1977823998 @default.
- W1569251007 cites W1977846928 @default.
- W1569251007 cites W1978804937 @default.
- W1569251007 cites W1978880341 @default.
- W1569251007 cites W1979129896 @default.
- W1569251007 cites W1980146732 @default.
- W1569251007 cites W1982089480 @default.
- W1569251007 cites W1983548148 @default.
- W1569251007 cites W1984713049 @default.
- W1569251007 cites W1984846162 @default.
- W1569251007 cites W1986167466 @default.
- W1569251007 cites W1986263266 @default.
- W1569251007 cites W1988561225 @default.
- W1569251007 cites W1988720723 @default.
- W1569251007 cites W1990777624 @default.
- W1569251007 cites W1991784998 @default.
- W1569251007 cites W1992337417 @default.
- W1569251007 cites W1992372295 @default.
- W1569251007 cites W1993665644 @default.
- W1569251007 cites W1996840228 @default.
- W1569251007 cites W1997603746 @default.
- W1569251007 cites W2000312216 @default.
- W1569251007 cites W2000502572 @default.
- W1569251007 cites W2002842091 @default.
- W1569251007 cites W2003285279 @default.
- W1569251007 cites W2003505203 @default.
- W1569251007 cites W2006422919 @default.
- W1569251007 cites W2008140229 @default.
- W1569251007 cites W2012384963 @default.
- W1569251007 cites W2016575029 @default.
- W1569251007 cites W2017191884 @default.
- W1569251007 cites W2018888883 @default.
- W1569251007 cites W2020625440 @default.
- W1569251007 cites W2020629886 @default.
- W1569251007 cites W2021099633 @default.
- W1569251007 cites W2022968291 @default.
- W1569251007 cites W2023400600 @default.
- W1569251007 cites W2023811880 @default.
- W1569251007 cites W2024973963 @default.
- W1569251007 cites W2024993897 @default.
- W1569251007 cites W2025223245 @default.
- W1569251007 cites W2027093651 @default.
- W1569251007 cites W2027094031 @default.
- W1569251007 cites W2029301289 @default.
- W1569251007 cites W2029394130 @default.
- W1569251007 cites W2029430119 @default.
- W1569251007 cites W2032247225 @default.
- W1569251007 cites W2033054691 @default.
- W1569251007 cites W2034296548 @default.
- W1569251007 cites W2034546847 @default.
- W1569251007 cites W2037224772 @default.
- W1569251007 cites W2037696369 @default.
- W1569251007 cites W2038514347 @default.
- W1569251007 cites W2038599949 @default.
- W1569251007 cites W2039560412 @default.