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- W1569256603 abstract "Abstract The inhibition in vitro of a highly purified preparation of mevalonate kinase by terpenyl pyrophosphates has been studied. Geranyl-PP and farnesyl-PP are potent inhibitors, while isopentenyl-PP, dimethylallyl-PP, and inorganic pyrophosphate do not inhibit significantly. The kinetics of geranyl-PP inhibition were investigated further and found to be uncompetitive with respect to mevalonic acid and competitive with respect to MgATP2-. Computer analysis of the data gave values of 2.65 ± 0.14 µm for Kii and 1.19 ± 0.12 µm for Kis. These results are consistent with the suggestion that geranyl-PP and farnesyl-PP act as physiological controls over farnesyl-PP biosynthesis and ATP utilization." @default.
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- W1569256603 date "1968-09-01" @default.
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- W1569256603 title "The Inhibition of Mevalonic Kinase by Geranyl and Farnesyl Pyrophosphates" @default.
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- W1569256603 doi "https://doi.org/10.1016/s0021-9258(18)93170-4" @default.
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