FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1569279743> ?p ?o ?g. }

• W1569279743 endingPage "101" @default.
• W1569279743 startingPage "94" @default.
• W1569279743 abstract "In this paper, we describe a temperature-sensitive mutant of the yeast Saccharomyces cerevisiae (P5-9) which at a restrictive temperature (36 degrees C) shows a pleiotropic defect for transport of many different metabolites. The temperature sensitivity of the mutant is closely related to a reduction in phosphofructokinase activity. This conclusion is based on the following criteria. (i) Both the primary isolate, designated P5-9 (ts [rho-] Ino-), which is an inositol auxotroph and respiration deficient, and a purified derivative, SB4 (ts [rho+] Ino+ ), which is respiration competent and capable of growing in the absence of inositol, are temperature sensitive for growth and ethanol production in media containing glucose or fructose as the sole carbon source. (ii) The respiration-competent derivative SB4 is not temperature sensitive in media containing glycerol or glycerol-pyruvate; glucose inhibits its growth at 36 degrees C in these media. (iii) Assays of glycolytic enzymes in P5-9 and SB4 extracts, prepared from cells incubated for 1 to 2 h at 36 degrees C before harvesting, show selective reduction in phosphofructokinase activity. Analysis of tetrads derived from the cross of mutant and nonmutant haploids indicates that temperature sensitivity for growth is due to a single gene or to two closely linked genes. The biochemical analysis of spores from seven such tetrads revealed a uniform cosegregation of temperature sensitivity for growth and phosphofructokinase activity. Transport and ATP levels were drastically reduced in SB4 cells incubated at 36 degrees C for 1 to 2 h with glucose as the carbon source, but not when glycerol-pyruvate or lactate was the energy source. Therefore, depletion of energy as a result of phosphofructokinase inactivation appears to be the cause of the pleiotropic transport defect observed in the mutant." @default.
• W1569279743 created "2016-06-24" @default.
• W1569279743 creator A5021558137 @default.
• W1569279743 creator A5024550400 @default.
• W1569279743 creator A5076756090 @default.
• W1569279743 date "1984-04-01" @default.
• W1569279743 modified "2023-09-28" @default.
• W1569279743 title "Physiology of a temperature-sensitive mutant of Saccharomyces cerevisiae defective in phosphofructokinase activity" @default.
• W1569279743 cites W1488548087 @default.
• W1569279743 cites W1496361100 @default.
• W1569279743 cites W1503233261 @default.
• W1569279743 cites W1526477746 @default.
• W1569279743 cites W1570915566 @default.
• W1569279743 cites W1604978036 @default.
• W1569279743 cites W1636225566 @default.
• W1569279743 cites W1775749144 @default.
• W1569279743 cites W1859876210 @default.
• W1569279743 cites W1982591275 @default.
• W1569279743 cites W1998225482 @default.
• W1569279743 cites W2007308795 @default.
• W1569279743 cites W2022212175 @default.
• W1569279743 cites W2023019055 @default.
• W1569279743 cites W2037718044 @default.
• W1569279743 cites W2048487254 @default.
• W1569279743 cites W2071989896 @default.
• W1569279743 cites W2095111890 @default.
• W1569279743 cites W2120710805 @default.
• W1569279743 cites W81970819 @default.
• W1569279743 doi "https://doi.org/10.1128/jb.158.1.94-101.1984" @default.
• W1569279743 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/215384" @default.
• W1569279743 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6232262" @default.
• W1569279743 hasPublicationYear "1984" @default.
• W1569279743 type Work @default.
• W1569279743 sameAs 1569279743 @default.
• W1569279743 citedByCount "1" @default.
• W1569279743 crossrefType "journal-article" @default.
• W1569279743 hasAuthorship W1569279743A5021558137 @default.
• W1569279743 hasAuthorship W1569279743A5024550400 @default.
• W1569279743 hasAuthorship W1569279743A5076756090 @default.
• W1569279743 hasBestOaLocation W15692797431 @default.
• W1569279743 hasConcept C104317684 @default.
• W1569279743 hasConcept C122245378 @default.
• W1569279743 hasConcept C143065580 @default.
• W1569279743 hasConcept C170493617 @default.
• W1569279743 hasConcept C181199279 @default.
• W1569279743 hasConcept C182215343 @default.
• W1569279743 hasConcept C20251656 @default.
• W1569279743 hasConcept C20950039 @default.
• W1569279743 hasConcept C2776970464 @default.
• W1569279743 hasConcept C2777427919 @default.
• W1569279743 hasConcept C2777576037 @default.
• W1569279743 hasConcept C2779222958 @default.
• W1569279743 hasConcept C2780881558 @default.
• W1569279743 hasConcept C55493867 @default.
• W1569279743 hasConcept C59822182 @default.
• W1569279743 hasConcept C86803240 @default.
• W1569279743 hasConceptScore W1569279743C104317684 @default.
• W1569279743 hasConceptScore W1569279743C122245378 @default.
• W1569279743 hasConceptScore W1569279743C143065580 @default.
• W1569279743 hasConceptScore W1569279743C170493617 @default.
• W1569279743 hasConceptScore W1569279743C181199279 @default.
• W1569279743 hasConceptScore W1569279743C182215343 @default.
• W1569279743 hasConceptScore W1569279743C20251656 @default.
• W1569279743 hasConceptScore W1569279743C20950039 @default.
• W1569279743 hasConceptScore W1569279743C2776970464 @default.
• W1569279743 hasConceptScore W1569279743C2777427919 @default.
• W1569279743 hasConceptScore W1569279743C2777576037 @default.
• W1569279743 hasConceptScore W1569279743C2779222958 @default.
• W1569279743 hasConceptScore W1569279743C2780881558 @default.
• W1569279743 hasConceptScore W1569279743C55493867 @default.
• W1569279743 hasConceptScore W1569279743C59822182 @default.
• W1569279743 hasConceptScore W1569279743C86803240 @default.
• W1569279743 hasIssue "1" @default.
• W1569279743 hasLocation W15692797431 @default.
• W1569279743 hasLocation W15692797432 @default.
• W1569279743 hasLocation W15692797433 @default.
• W1569279743 hasOpenAccess W1569279743 @default.
• W1569279743 hasPrimaryLocation W15692797431 @default.
• W1569279743 hasRelatedWork W1488548087 @default.
• W1569279743 hasRelatedWork W1946155066 @default.
• W1569279743 hasRelatedWork W1969022698 @default.
• W1569279743 hasRelatedWork W1977772517 @default.
• W1569279743 hasRelatedWork W1978520220 @default.
• W1569279743 hasRelatedWork W1982086308 @default.
• W1569279743 hasRelatedWork W1995956297 @default.
• W1569279743 hasRelatedWork W2004377880 @default.
• W1569279743 hasRelatedWork W2019870956 @default.
• W1569279743 hasRelatedWork W2021810075 @default.
• W1569279743 hasRelatedWork W2033411840 @default.
• W1569279743 hasRelatedWork W2053534344 @default.
• W1569279743 hasRelatedWork W2063238607 @default.
• W1569279743 hasRelatedWork W2074294910 @default.
• W1569279743 hasRelatedWork W2086859110 @default.
• W1569279743 hasRelatedWork W2095111890 @default.
• W1569279743 hasRelatedWork W2125957681 @default.
• W1569279743 hasRelatedWork W2138498879 @default.
• W1569279743 hasRelatedWork W2151258701 @default.
• W1569279743 hasRelatedWork W2380698398 @default.

• next