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- W1569282859 abstract "Activation of pinealocyte α1-adrenergic receptors enhances the induction of 5-hydroxytryptamine (5-HT) N-acetyltransferase, the rate-limiting enzyme in the synthesis of the pineal hormone, melatonin by potentiating β-adrenergic-receptor stimulation of cAMP synthesis. In the present study, the physiological role of α1-adrenergic mechanisms in regulating the nocturnal elevation in 5-HT N-acetyltransferase (NAT) activity was investigated in the rat using the selective α1-adrenergic antagonist, prazosin.When injected subcutaneously, both just before dark onset and at mid-dark, prazosin significantly reduced night-time NAT activity, indicating that α1-adrenergic mechanisms play an important role in regulating endogenous melatonin synthesis." @default.
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- W1569282859 date "1995-01-01" @default.
- W1569282859 modified "2023-09-23" @default.
- W1569282859 title "Nocturnal Induction of Rat Pineal N‐Acetyltransferase Activity can be Reduced by α1‐Adrenergic‐receptor Blockade" @default.
- W1569282859 doi "https://doi.org/10.1111/j.2042-7158.1995.tb00350.x" @default.
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