FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1569283491> ?p ?o ?g. }

• W1569283491 endingPage "157" @default.
• W1569283491 startingPage "143" @default.
• W1569283491 abstract "The 1979 amino acid sequence of embryonic chicken gizzard smooth muscle myosin heavy chain (MHC) hase been determined by cloning and sequencing its cDNA. Genomic Southern analysis and Northern analysis with the cDNA sequence show that gizzard MHC is encoded by a single-copy gene, and this gene is expressed in the gizzard and aorta. The encoded protein has a calculated Mr of 229 × 103, and can be divided into a long α-helical rod and a globular head. Only 32 to 33% of the amino acid residues in the rod and 48 to 49% in the head are conserved when compared with nematode or vertebrate sarcomeric MHC sequences. However, the seven residue hydrophobic periodicity, together with the 28 and 196 residue repeat of charge distribution previously described in nematode myosin rod, are all present in the gizzard myosin rod. Two of the trypsin-sensitive sites in gizzard light meromyosin have been mapped by partial peptide sequencing to 99 nm and 60 nm from the tip of the myosin tail, where these sites coincide with the two “hinges” for the 6S/10S transition. In the head sequence, several polypeptide segments, including the regions around the putative ATP-binding site and the reactive thiol groups, are highly conserved. These areas presumably reflect conserved structural elements important for the function of myosin. A multi-domain folding model of myosin head is proposed on the basis of the conserved sequences, information on the topography of myosin in the literature, and the predicted secondary structures. In this model, Mg2+ ATP is bound to a pocket between two opposing αβ domains, while actin undergoes electrostatic interactions with lysine-rich surface loops on two other domains. The actin-myosin interactions are thought to be modulated through relative movements of the domains induced by the binding of ATP." @default.
• W1569283491 created "2016-06-24" @default.
• W1569283491 creator A5006145523 @default.
• W1569283491 creator A5063380744 @default.
• W1569283491 creator A5081126904 @default.
• W1569283491 creator A5081622324 @default.
• W1569283491 creator A5081677574 @default.
• W1569283491 creator A5084505854 @default.
• W1569283491 date "1987-11-01" @default.
• W1569283491 modified "2023-09-25" @default.
• W1569283491 title "Complete primary structure of vertebrate smooth muscle myosin heavy chain deduced from its complementary DNA sequence" @default.
• W1569283491 cites W124504601 @default.
• W1569283491 cites W1440519446 @default.
• W1569283491 cites W1485162707 @default.
• W1569283491 cites W1503210396 @default.
• W1569283491 cites W1505533897 @default.
• W1569283491 cites W1507106534 @default.
• W1569283491 cites W1518601146 @default.
• W1569283491 cites W1540882200 @default.
• W1569283491 cites W1549063714 @default.
• W1569283491 cites W1558285759 @default.
• W1569283491 cites W1567369841 @default.
• W1569283491 cites W1567482657 @default.
• W1569283491 cites W1576767939 @default.
• W1569283491 cites W1578752164 @default.
• W1569283491 cites W1593102911 @default.
• W1569283491 cites W1601687245 @default.
• W1569283491 cites W1605178447 @default.
• W1569283491 cites W161645565 @default.
• W1569283491 cites W1759875777 @default.
• W1569283491 cites W1790458031 @default.
• W1569283491 cites W1831223506 @default.
• W1569283491 cites W1845352492 @default.
• W1569283491 cites W1852153177 @default.
• W1569283491 cites W189553755 @default.
• W1569283491 cites W1906781755 @default.
• W1569283491 cites W1913743281 @default.
• W1569283491 cites W1958392984 @default.
• W1569283491 cites W1965380851 @default.
• W1569283491 cites W1966193664 @default.
• W1569283491 cites W1970176740 @default.
• W1569283491 cites W1972056569 @default.
• W1569283491 cites W1973466955 @default.
• W1569283491 cites W1979304607 @default.
• W1569283491 cites W1980879342 @default.
• W1569283491 cites W1983093403 @default.
• W1569283491 cites W1984322384 @default.
• W1569283491 cites W1987034229 @default.
• W1569283491 cites W1987589427 @default.
• W1569283491 cites W1990379370 @default.
• W1569283491 cites W1992499210 @default.
• W1569283491 cites W1994054808 @default.
• W1569283491 cites W1995981593 @default.
• W1569283491 cites W1996537553 @default.
• W1569283491 cites W1997869261 @default.
• W1569283491 cites W2002283054 @default.
• W1569283491 cites W2007751924 @default.
• W1569283491 cites W2009105413 @default.
• W1569283491 cites W2010180393 @default.
• W1569283491 cites W2010207613 @default.
• W1569283491 cites W2014764417 @default.
• W1569283491 cites W2022402206 @default.
• W1569283491 cites W2023089345 @default.
• W1569283491 cites W2024636412 @default.
• W1569283491 cites W2026373135 @default.
• W1569283491 cites W2028622989 @default.
• W1569283491 cites W2028784867 @default.
• W1569283491 cites W2030705265 @default.
• W1569283491 cites W2039358467 @default.
• W1569283491 cites W2042943962 @default.
• W1569283491 cites W2044648543 @default.
• W1569283491 cites W2045425113 @default.
• W1569283491 cites W2045913132 @default.
• W1569283491 cites W2055883955 @default.
• W1569283491 cites W2059890422 @default.
• W1569283491 cites W2061018794 @default.
• W1569283491 cites W2063396636 @default.
• W1569283491 cites W2064272399 @default.
• W1569283491 cites W2066606020 @default.
• W1569283491 cites W2068316370 @default.
• W1569283491 cites W2077915501 @default.
• W1569283491 cites W2080249964 @default.
• W1569283491 cites W2092236849 @default.
• W1569283491 cites W2095415806 @default.
• W1569283491 cites W2097055994 @default.
• W1569283491 cites W2113403117 @default.
• W1569283491 cites W2115607297 @default.
• W1569283491 cites W2139292873 @default.
• W1569283491 cites W2177861138 @default.
• W1569283491 cites W2291087670 @default.
• W1569283491 doi "https://doi.org/10.1016/0022-2836(87)90302-0" @default.
• W1569283491 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2892941" @default.
• W1569283491 hasPublicationYear "1987" @default.
• W1569283491 type Work @default.
• W1569283491 sameAs 1569283491 @default.
• W1569283491 citedByCount "191" @default.
• W1569283491 countsByYear W15692834912012 @default.
• W1569283491 countsByYear W15692834912020 @default.

• next