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- W1569285136 abstract "To investigate glycoprotein-1b (GP-1b) expression on platelets from patients with acute myeloid leukemia (AML).Purified platelets, obtained from AML-patients and normal control subjects, were examined for surface membrane GP1b-expression by flow cytometry and GP1b-mediated aggregation responses by aggregometry. The level of elastase in plasma from patients and controls was measured by enzymed-linked immunosorbent assay. The whole of this work was carried out at the University of Liverpool, Liverpool, United Kingdom during the period of 1994-2001.Platelets from the majority of AML-patients showed reduced GP1b-expression and reduced GP1b-mediated aggregation responses. Reduction in platelet GP1b-expression was associated with increased plasma elastase levels.The present study suggests that elastase, released from leukemic blasts, degrades platelet GP1b, resulting in dysfunctional circulating platelets in AML-patients. These results could explain the bleeding disorders observed in these patients." @default.
- W1569285136 created "2016-06-24" @default.
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- W1569285136 date "2005-07-01" @default.
- W1569285136 modified "2023-09-23" @default.
- W1569285136 title "An acquired form of Bernard Soulier syndrome associated with acute myeloid leukemia." @default.
- W1569285136 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16047060" @default.
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