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• W1569286053 abstract "Summary γδ T cells link innate and adaptive immune systems and may regulate host defence. Their role in systemic inflammation induced by trauma or infection (sepsis) is still obscured. The present study was aimed to investigate functions of lung γδ T cells and their response to experimental sepsis. Mice were subjected to caecal ligation and puncture (CLP) to induce sepsis and acute lung injury (ALI), or to the sham operation. Animals were killed 1, 4, and 7 days postoperatively; lungs were examined by histology, and isolated cells were studied by flow cytometry. Absolute number of γδ T cells progressively increased in lungs during sepsis, and reached a seven‐fold increase at day 7 after CLP (3·84 ± 0·41 × 10 5 /lung; P = 0·0002 versus sham). A cellular dysfunction was revealed one day after CLP, as manifested by low cytolytic activity (22·3 ± 7·1%; P < 0·05 versus sham), low interferon‐γ (IFN‐γ; 8·5 ± 2·5%; P < 0·05 versus control) and interleukin‐10 (IL‐10) expression, and high tumour necrosis factor‐α expression (19·5 ± 1·7%; P < 0·05 versus control). The restoration of cytotoxicity, and increase in IFN‐γ and IL‐10 expression was observed at day 7 of CLP‐induced sepsis. In summary, our results demonstrate significant progressive accumulation of γδ T cells in lungs during CLP‐induced ALI. The temporary functional suppression of lung γδ T cells found early after CLP may influence the outcome of sepsis, possibly being associated with uncontrolled inflammatory lung damage." @default.
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• W1569286053 date "2004-04-16" @default.
• W1569286053 modified "2023-10-16" @default.
• W1569286053 title "Response of lung gammadelta T cells to experimental sepsis in mice" @default.
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• W1569286053 doi "https://doi.org/10.1111/j.1365-2567.2004.01854.x" @default.
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