Matches in SemOpenAlex for { <https://semopenalex.org/work/W1569290580> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W1569290580 endingPage "16064" @default.
- W1569290580 startingPage "16059" @default.
- W1569290580 abstract "The ability of P-glycoprotein (P-gp) to transport naturally occurring and synthetic opiate analgesics was investigated. Multidrug-resistant Chinese hamster ovary cells (B30) were found to accumulate significantly lower amounts of morphine than their drug-sensitive counterparts (B1). This decreased accumulation was reversed upon depletion of cellular stores of ATP. In addition, morphine bound to plasma membranes from B30 cells in a specific, saturable fashion. Verapamil and vinblastine, compounds transported by P-gp, were able to increase accumulation and displace the binding of morphine in B30 cells. In turn, the synthetic opiates meperidine, pentazocine, and methadone were able to increase the accumulation of vinblastine in resistant cells. These compounds were also able to displace the specific binding of vinblastine and the photoaffinity labeling of P-gp in plasma membranes by the radioiodinated anthracycline, iodomycin. The implications of these findings in relation to the distribution, tolerance, and gastrointestinal side effects of opiates are discussed." @default.
- W1569290580 created "2016-06-24" @default.
- W1569290580 creator A5049400835 @default.
- W1569290580 creator A5053463680 @default.
- W1569290580 date "1993-07-01" @default.
- W1569290580 modified "2023-10-14" @default.
- W1569290580 title "Synthetic and natural opiates interact with P-glycoprotein in multidrug-resistant cells" @default.
- W1569290580 cites W1499694712 @default.
- W1569290580 cites W1519177607 @default.
- W1569290580 cites W1531911812 @default.
- W1569290580 cites W1549117291 @default.
- W1569290580 cites W1585153381 @default.
- W1569290580 cites W1595188935 @default.
- W1569290580 cites W1596439003 @default.
- W1569290580 cites W1646976215 @default.
- W1569290580 cites W1964470226 @default.
- W1569290580 cites W1979103854 @default.
- W1569290580 cites W1996845076 @default.
- W1569290580 cites W1997241897 @default.
- W1569290580 cites W2025603165 @default.
- W1569290580 cites W2039704972 @default.
- W1569290580 cites W2039864751 @default.
- W1569290580 cites W2049085947 @default.
- W1569290580 cites W2049520769 @default.
- W1569290580 cites W2058588242 @default.
- W1569290580 cites W2084088795 @default.
- W1569290580 cites W2091803979 @default.
- W1569290580 cites W2097878215 @default.
- W1569290580 cites W2114089489 @default.
- W1569290580 doi "https://doi.org/10.1016/s0021-9258(18)82357-2" @default.
- W1569290580 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8101846" @default.
- W1569290580 hasPublicationYear "1993" @default.
- W1569290580 type Work @default.
- W1569290580 sameAs 1569290580 @default.
- W1569290580 citedByCount "137" @default.
- W1569290580 countsByYear W15692905802012 @default.
- W1569290580 countsByYear W15692905802013 @default.
- W1569290580 countsByYear W15692905802014 @default.
- W1569290580 countsByYear W15692905802015 @default.
- W1569290580 countsByYear W15692905802016 @default.
- W1569290580 countsByYear W15692905802017 @default.
- W1569290580 countsByYear W15692905802018 @default.
- W1569290580 countsByYear W15692905802019 @default.
- W1569290580 countsByYear W15692905802020 @default.
- W1569290580 countsByYear W15692905802021 @default.
- W1569290580 countsByYear W15692905802022 @default.
- W1569290580 crossrefType "journal-article" @default.
- W1569290580 hasAuthorship W1569290580A5049400835 @default.
- W1569290580 hasAuthorship W1569290580A5053463680 @default.
- W1569290580 hasBestOaLocation W15692905801 @default.
- W1569290580 hasConcept C133936738 @default.
- W1569290580 hasConcept C185592680 @default.
- W1569290580 hasConcept C2778707650 @default.
- W1569290580 hasConcept C501593827 @default.
- W1569290580 hasConcept C55493867 @default.
- W1569290580 hasConcept C86803240 @default.
- W1569290580 hasConcept C98274493 @default.
- W1569290580 hasConceptScore W1569290580C133936738 @default.
- W1569290580 hasConceptScore W1569290580C185592680 @default.
- W1569290580 hasConceptScore W1569290580C2778707650 @default.
- W1569290580 hasConceptScore W1569290580C501593827 @default.
- W1569290580 hasConceptScore W1569290580C55493867 @default.
- W1569290580 hasConceptScore W1569290580C86803240 @default.
- W1569290580 hasConceptScore W1569290580C98274493 @default.
- W1569290580 hasIssue "21" @default.
- W1569290580 hasLocation W15692905801 @default.
- W1569290580 hasOpenAccess W1569290580 @default.
- W1569290580 hasPrimaryLocation W15692905801 @default.
- W1569290580 hasRelatedWork W1998956539 @default.
- W1569290580 hasRelatedWork W1999906254 @default.
- W1569290580 hasRelatedWork W2016114543 @default.
- W1569290580 hasRelatedWork W2031866272 @default.
- W1569290580 hasRelatedWork W2074950338 @default.
- W1569290580 hasRelatedWork W2091807474 @default.
- W1569290580 hasRelatedWork W2382225335 @default.
- W1569290580 hasRelatedWork W2497337421 @default.
- W1569290580 hasRelatedWork W2950442272 @default.
- W1569290580 hasRelatedWork W4226166860 @default.
- W1569290580 hasVolume "268" @default.
- W1569290580 isParatext "false" @default.
- W1569290580 isRetracted "false" @default.
- W1569290580 magId "1569290580" @default.
- W1569290580 workType "article" @default.