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- W1569292546 abstract "Sickle cell anaemia is a genetic disease, whose indispensable feature is the presence of a mutation in the beta globin gene that specifies one of the chains of haemoglobin. This mutation endows the haemoglobin with a new property: the capacity of polymerizing when deoxygenated. This mutation has several untoward consequences: haemolytic anaemia, acute chest syndrome, stroke, renal insufficiency, leg ulcers, osteonecrosis, etc. Lifespan is compromised and the only accepted treatment is hydroxyurea, which is capable of ameliorating the phenotype and extending the life of the patient." @default.
- W1569292546 created "2016-06-24" @default.
- W1569292546 creator A5056789730 @default.
- W1569292546 date "2006-01-27" @default.
- W1569292546 modified "2023-10-18" @default.
- W1569292546 title "Sickle Cell Anaemia" @default.
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- W1569292546 doi "https://doi.org/10.1038/npg.els.0001454" @default.
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