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- W1569298265 endingPage "137" @default.
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- W1569298265 abstract "The endocannabinoid (eCB) system has emerged as a versatile regulator of mammalian physiology, both in neuronal and non-neuronal cells and organs, from embryonic development to adult physiology and senescence. The eCB system is widely distributed within the mammalian organism, and is prominently present in the central and peripheral nervous system, but also in many non-neuronal tissues. Consequently, the eCB system regulates numerous physiological functions. Furthermore, the widespread distribution of the many components of the eCB system leads to highly complex cannabinoid pharmacology. Examples of the power of genetic approaches are given this chapter for answering questions such as: (i) how do exogenously applied cannabinoids evoke their broad spectrum of pharmacological effects; (ii) can we understand the mechanisms underlying the therapeutically beneficial effects and unwanted side-effects; and (iii) how is the eCB synthesis and degradation machinery integrated into the general lipid metabolisms and into other related lipid signalling systems." @default.
- W1569298265 created "2016-06-24" @default.
- W1569298265 creator A5023263973 @default.
- W1569298265 date "2014-07-18" @default.
- W1569298265 modified "2023-09-25" @default.
- W1569298265 title "Genetic dissection of the endocannabinoid system and how it changed our knowledge of cannabinoid pharmacology and mammalian physiology" @default.
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