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• W1569306930 abstract "Dynein light chains are accessory subunits of the cytoplasmic dynein complex, a minus-end directed microtubule motor. Here, we demonstrate that the dynein light chain Tctex-1 associates with unattached kinetochores and is essential for accurate chromosome segregation. Tctex-1 knockdown in cells does not affect the localization and function of dynein at the kinetochore, but produces a prolonged mitotic arrest with a few misaligned chromosomes, which are subsequently missegregated during anaphase. This function is independent of Tctex-1's association with dynein. The kinetochore localization of Tctex-1 is independent of the ZW10-dynein pathway, but requires the Ndc80 complex. Thus, our findings reveal a dynein independent role of Tctex-1 at the kinetochore to enhance the stability of kinetochore-microtubule attachment." @default.
• W1569306930 created "2016-06-24" @default.
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• W1569306930 date "2015-04-30" @default.
• W1569306930 modified "2023-10-03" @default.
• W1569306930 title "A dynein independent role of Tctex-1 at the kinetochore" @default.
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• W1569306930 doi "https://doi.org/10.1080/15384101.2014.1000217" @default.
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