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- W1569309546 abstract "It has been demonstrated in invertebrate species that the evolutionarily conserved insulin and insulin-like growth factor (IGF) signaling (IIS) pathway plays a major role in the control of longevity. In the roundworm Caenorhabditis elegans, single mutations that diminish insulin/IGF-1 signaling can increase lifespan more than twofold and cause the animal to remain active and youthful much longer than normal. Likewise, substantial increases in lifespan are associated with mutations that reduce insulin/IGF-1 signaling in the fruit fly Drosophila melanogaster. In invertebrates, multiple insulin-like ligands exist that bind to a common single insulin/IGF-1 like receptor. In contrast, in mammals, different receptors exist that bind insulin, IGF-1 and IGF-2 with different affinities. In several mouse models, mutations that are associated with decreased GH/IGF-1 signaling or decreased insulin signaling have been associated with enhanced lifespan. However, the increased complexity of the mammalian insulin/IGF-1 system has made it difficult to separate the roles of insulin, GH and IGF-1 in mammalian longevity. Likewise, the relevance of reduced insulin and IGF-1 signaling in human longevity remains controversial. However, studies on the genetic and metabolic characteristics that are associated with healthy longevity and old age survival suggest that the conserved ancient IIS pathway may also play a role in human longevity." @default.
- W1569309546 created "2016-06-24" @default.
- W1569309546 creator A5035860380 @default.
- W1569309546 date "2010-10-01" @default.
- W1569309546 modified "2023-09-23" @default.
- W1569309546 title "Insulin, IGF-1 and longevity." @default.
- W1569309546 cites W12064739 @default.
- W1569309546 cites W1503853782 @default.
- W1569309546 cites W1523160355 @default.
- W1569309546 cites W1542474163 @default.
- W1569309546 cites W1631908837 @default.
- W1569309546 cites W1822251675 @default.
- W1569309546 cites W1960692735 @default.
- W1569309546 cites W1964779097 @default.
- W1569309546 cites W1965684670 @default.
- W1569309546 cites W1969851244 @default.
- W1569309546 cites W1974044617 @default.
- W1569309546 cites W1975439264 @default.
- W1569309546 cites W1977701732 @default.
- W1569309546 cites W1983669217 @default.
- W1569309546 cites W1985425785 @default.
- W1569309546 cites W1986896225 @default.
- W1569309546 cites W1988614711 @default.
- W1569309546 cites W1990076171 @default.
- W1569309546 cites W1992444358 @default.
- W1569309546 cites W1997146974 @default.
- W1569309546 cites W1998493448 @default.
- W1569309546 cites W2000923281 @default.
- W1569309546 cites W2003849432 @default.
- W1569309546 cites W2007071366 @default.
- W1569309546 cites W2009172922 @default.
- W1569309546 cites W2015402685 @default.
- W1569309546 cites W2020266111 @default.
- W1569309546 cites W2020887103 @default.
- W1569309546 cites W2037808521 @default.
- W1569309546 cites W2047683380 @default.
- W1569309546 cites W2049009766 @default.
- W1569309546 cites W2052722944 @default.
- W1569309546 cites W2055708395 @default.
- W1569309546 cites W2058484936 @default.
- W1569309546 cites W2059144648 @default.
- W1569309546 cites W2061431107 @default.
- W1569309546 cites W2062629127 @default.
- W1569309546 cites W2066317254 @default.
- W1569309546 cites W2066519654 @default.
- W1569309546 cites W2066727453 @default.
- W1569309546 cites W2069988949 @default.
- W1569309546 cites W2075645766 @default.
- W1569309546 cites W2076964620 @default.
- W1569309546 cites W2080094749 @default.
- W1569309546 cites W2082852887 @default.
- W1569309546 cites W2089527908 @default.
- W1569309546 cites W2094231976 @default.
- W1569309546 cites W2096452837 @default.
- W1569309546 cites W2096541004 @default.
- W1569309546 cites W2099547258 @default.
- W1569309546 cites W2100701743 @default.
- W1569309546 cites W2101178614 @default.
- W1569309546 cites W2103416697 @default.
- W1569309546 cites W2113466108 @default.
- W1569309546 cites W2119057118 @default.
- W1569309546 cites W2121881475 @default.
- W1569309546 cites W2126590177 @default.
- W1569309546 cites W2132631648 @default.
- W1569309546 cites W2137720344 @default.
- W1569309546 cites W2140984295 @default.
- W1569309546 cites W2144005841 @default.
- W1569309546 cites W2144498949 @default.
- W1569309546 cites W2148267502 @default.
- W1569309546 cites W2150759685 @default.
- W1569309546 cites W2151666828 @default.
- W1569309546 cites W2152101492 @default.
- W1569309546 cites W2156088513 @default.
- W1569309546 cites W2159979637 @default.
- W1569309546 cites W2160420618 @default.
- W1569309546 cites W2162306102 @default.
- W1569309546 cites W2164468190 @default.
- W1569309546 cites W2165913642 @default.
- W1569309546 cites W2166146113 @default.
- W1569309546 cites W2170269651 @default.
- W1569309546 cites W2172214973 @default.
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