Matches in SemOpenAlex for { <https://semopenalex.org/work/W1569317053> ?p ?o ?g. }
- W1569317053 abstract "Escherichia coli O157:H7 is a human pathogen capable of causing severe disease due to the release of the phage-encoded exotoxin Shiga toxin (Stx). The primaryreservoir of E. coli O157:H7 is cattle from which the organism is shed asymptomatically and colonises specifically at the terminal rectum (TR). Prevalencerates in cattle vary and shedding is transient making determination of transmission routes difficult. This thesis aims to gain further understanding of shedding patternsand transmission of E. coli O157:H7 in cattle to inform future control strategies.Rates of E. coli O157:H7 replication in gut contents and exceptional replication rates in TR mucus revealed that passive shedding could explain both low and high faecalcounts observed in epidemiological studies and that replication in TR mucus coincides with high rates of attachment to bovine terminal rectum epithelial (BTRE)cells. The rumen was identified as a critical point of control of bacterial numbers which could be exploited in future control strategies which should also consider thepotential for passive shedding and environmental replication to maintain E. coli O157:H7 populations on farms in the absence of a colonised animal.Transmission studies showed that while useful for studying colonisation of cattle, Stx- strains of E. coli O157:H7 are unable to transmit effectively compared to Stx+ strains and are not appropriate for use in experimental transmission studies.Differences observed between shedding and transmission of phage type (PT) 21/28 and PT 32 strains could explain why PT 21/28 is more common in cattle and humans.Studies of replication and colonisation of the strains from the transmission studies revealed that PT 21/28 is better able to replicate, attach and increase in number on BTRE cells compared to PT 32 and Stx- W3. These advantages to survival and colonisation indicate how PT 21/28 strains could out-compete other strains to persist in cattle populations." @default.
- W1569317053 created "2016-06-24" @default.
- W1569317053 creator A5020099151 @default.
- W1569317053 date "2013-08-30" @default.
- W1569317053 modified "2023-09-27" @default.
- W1569317053 title "UNDERSTANDING PATTERNS OF ESCHERICHIA COLI O157:H7 SHEDDING AND COLONISATION IN CATTLE AND THEIR ROLE IN TRANSMISSION" @default.
- W1569317053 cites W10177963 @default.
- W1569317053 cites W142507464 @default.
- W1569317053 cites W1460465682 @default.
- W1569317053 cites W1495502437 @default.
- W1569317053 cites W1512857274 @default.
- W1569317053 cites W1514445266 @default.
- W1569317053 cites W1529103661 @default.
- W1569317053 cites W1529999490 @default.
- W1569317053 cites W1538707760 @default.
- W1569317053 cites W1540832897 @default.
- W1569317053 cites W1559495947 @default.
- W1569317053 cites W1606913541 @default.
- W1569317053 cites W16079015 @default.
- W1569317053 cites W1860937064 @default.
- W1569317053 cites W1885356084 @default.
- W1569317053 cites W1895716945 @default.
- W1569317053 cites W1907001285 @default.
- W1569317053 cites W1912451872 @default.
- W1569317053 cites W1946252749 @default.
- W1569317053 cites W1957536085 @default.
- W1569317053 cites W1958731373 @default.
- W1569317053 cites W1963836867 @default.
- W1569317053 cites W1964868893 @default.
- W1569317053 cites W1966597734 @default.
- W1569317053 cites W1966789105 @default.
- W1569317053 cites W1968294861 @default.
- W1569317053 cites W1969527705 @default.
- W1569317053 cites W1969564514 @default.
- W1569317053 cites W1978707321 @default.
- W1569317053 cites W1980515499 @default.
- W1569317053 cites W1980663616 @default.
- W1569317053 cites W1981282204 @default.
- W1569317053 cites W1982542326 @default.
- W1569317053 cites W1985030909 @default.
- W1569317053 cites W1985503455 @default.
- W1569317053 cites W1988479009 @default.
- W1569317053 cites W1989165988 @default.
- W1569317053 cites W1989499196 @default.
- W1569317053 cites W1991194207 @default.
- W1569317053 cites W1992263339 @default.
- W1569317053 cites W1994146137 @default.
- W1569317053 cites W1995703571 @default.
- W1569317053 cites W1996446565 @default.
- W1569317053 cites W1999905096 @default.
- W1569317053 cites W2000254246 @default.
- W1569317053 cites W2003480978 @default.
- W1569317053 cites W2012210778 @default.
- W1569317053 cites W2012230803 @default.
- W1569317053 cites W2013381968 @default.
- W1569317053 cites W2015417882 @default.
- W1569317053 cites W2015804532 @default.
- W1569317053 cites W2017081120 @default.
- W1569317053 cites W2018146727 @default.
- W1569317053 cites W2019489332 @default.
- W1569317053 cites W2019618561 @default.
- W1569317053 cites W2024243377 @default.
- W1569317053 cites W2024941482 @default.
- W1569317053 cites W2025552324 @default.
- W1569317053 cites W2027548149 @default.
- W1569317053 cites W2029595663 @default.
- W1569317053 cites W2031957253 @default.
- W1569317053 cites W2033134248 @default.
- W1569317053 cites W2033804375 @default.
- W1569317053 cites W2033932013 @default.
- W1569317053 cites W2034018795 @default.
- W1569317053 cites W2035859404 @default.
- W1569317053 cites W2038916450 @default.
- W1569317053 cites W2039012384 @default.
- W1569317053 cites W2039361725 @default.
- W1569317053 cites W2041751952 @default.
- W1569317053 cites W2043770362 @default.
- W1569317053 cites W2047469981 @default.
- W1569317053 cites W2052789873 @default.
- W1569317053 cites W2054919436 @default.
- W1569317053 cites W2057096711 @default.
- W1569317053 cites W2057339701 @default.
- W1569317053 cites W2057460200 @default.
- W1569317053 cites W2064452752 @default.
- W1569317053 cites W2065635166 @default.
- W1569317053 cites W2069281061 @default.
- W1569317053 cites W2070525881 @default.
- W1569317053 cites W2071279193 @default.
- W1569317053 cites W2072290234 @default.
- W1569317053 cites W2073669353 @default.
- W1569317053 cites W2074615576 @default.
- W1569317053 cites W2077207224 @default.
- W1569317053 cites W2079285076 @default.
- W1569317053 cites W2080263009 @default.
- W1569317053 cites W2083995832 @default.
- W1569317053 cites W2086011609 @default.
- W1569317053 cites W2086667303 @default.
- W1569317053 cites W2088044381 @default.
- W1569317053 cites W2088991494 @default.
- W1569317053 cites W2091708538 @default.