Matches in SemOpenAlex for { <https://semopenalex.org/work/W1569325306> ?p ?o ?g. }
- W1569325306 endingPage "11" @default.
- W1569325306 startingPage "1" @default.
- W1569325306 abstract "Among the different signaling molecules released during reactive gliosis occurring in Alzheimer’s disease (AD), the astrocyte-derived S100B protein plays a key role in neuroinflammation, one of the hallmarks of the disease. The use of pharmacological tools targeting S100B may be crucial to embank its effects and some of the pathological features of AD. The antiprotozoal drug pentamidine is a good candidate since it directly blocks S100B activity by inhibiting its interaction with the tumor suppressor p53. We used a mouse model of amyloid beta- (A β -) induced AD, which is characterized by reactive gliosis and neuroinflammation in the brain, and we evaluated the effect of pentamidine on the main S100B-mediated events. Pentamidine caused the reduction of glial fibrillary acidic protein, S100B, and RAGE protein expression, which are signs of reactive gliosis, and induced p53 expression in astrocytes. Pentamidine also reduced the expression of proinflammatory mediators and markers, thus reducing neuroinflammation in AD brain. In parallel, we observed a significant neuroprotection exerted by pentamidine on CA1 pyramidal neurons. We demonstrated that pentamidine inhibits A β -induced gliosis and neuroinflammation in an animal model of AD, thus playing a role in slowing down the course of the disease." @default.
- W1569325306 created "2016-06-24" @default.
- W1569325306 creator A5002033752 @default.
- W1569325306 creator A5002304337 @default.
- W1569325306 creator A5014362120 @default.
- W1569325306 creator A5014566953 @default.
- W1569325306 creator A5031998312 @default.
- W1569325306 creator A5035417175 @default.
- W1569325306 creator A5043065519 @default.
- W1569325306 date "2015-01-01" @default.
- W1569325306 modified "2023-10-18" @default.
- W1569325306 title "S100B Inhibitor Pentamidine Attenuates Reactive Gliosis and Reduces Neuronal Loss in a Mouse Model of Alzheimer’s Disease" @default.
- W1569325306 cites W1501905284 @default.
- W1569325306 cites W1752819622 @default.
- W1569325306 cites W1896225205 @default.
- W1569325306 cites W1963568158 @default.
- W1569325306 cites W1970468452 @default.
- W1569325306 cites W1985839335 @default.
- W1569325306 cites W2010487701 @default.
- W1569325306 cites W2011610896 @default.
- W1569325306 cites W2012505933 @default.
- W1569325306 cites W2015186493 @default.
- W1569325306 cites W2031273497 @default.
- W1569325306 cites W2031648342 @default.
- W1569325306 cites W2035471044 @default.
- W1569325306 cites W2050401880 @default.
- W1569325306 cites W2055180596 @default.
- W1569325306 cites W2060085692 @default.
- W1569325306 cites W2061963598 @default.
- W1569325306 cites W2065419688 @default.
- W1569325306 cites W2070494722 @default.
- W1569325306 cites W2071675524 @default.
- W1569325306 cites W2079645429 @default.
- W1569325306 cites W2079815081 @default.
- W1569325306 cites W2080946103 @default.
- W1569325306 cites W2082429191 @default.
- W1569325306 cites W2082431283 @default.
- W1569325306 cites W2091740604 @default.
- W1569325306 cites W2094286956 @default.
- W1569325306 cites W2094690354 @default.
- W1569325306 cites W2095144224 @default.
- W1569325306 cites W2095969880 @default.
- W1569325306 cites W2112826148 @default.
- W1569325306 cites W2116784956 @default.
- W1569325306 cites W2144725045 @default.
- W1569325306 cites W2165092386 @default.
- W1569325306 cites W235749929 @default.
- W1569325306 cites W38748857 @default.
- W1569325306 cites W4240182676 @default.
- W1569325306 cites W4296759652 @default.
- W1569325306 doi "https://doi.org/10.1155/2015/508342" @default.
- W1569325306 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4532807" @default.
- W1569325306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26295040" @default.
- W1569325306 hasPublicationYear "2015" @default.
- W1569325306 type Work @default.
- W1569325306 sameAs 1569325306 @default.
- W1569325306 citedByCount "61" @default.
- W1569325306 countsByYear W15693253062016 @default.
- W1569325306 countsByYear W15693253062017 @default.
- W1569325306 countsByYear W15693253062018 @default.
- W1569325306 countsByYear W15693253062019 @default.
- W1569325306 countsByYear W15693253062020 @default.
- W1569325306 countsByYear W15693253062021 @default.
- W1569325306 countsByYear W15693253062022 @default.
- W1569325306 countsByYear W15693253062023 @default.
- W1569325306 crossrefType "journal-article" @default.
- W1569325306 hasAuthorship W1569325306A5002033752 @default.
- W1569325306 hasAuthorship W1569325306A5002304337 @default.
- W1569325306 hasAuthorship W1569325306A5014362120 @default.
- W1569325306 hasAuthorship W1569325306A5014566953 @default.
- W1569325306 hasAuthorship W1569325306A5031998312 @default.
- W1569325306 hasAuthorship W1569325306A5035417175 @default.
- W1569325306 hasAuthorship W1569325306A5043065519 @default.
- W1569325306 hasBestOaLocation W15693253061 @default.
- W1569325306 hasConcept C126322002 @default.
- W1569325306 hasConcept C142724271 @default.
- W1569325306 hasConcept C164027704 @default.
- W1569325306 hasConcept C169760540 @default.
- W1569325306 hasConcept C203014093 @default.
- W1569325306 hasConcept C204232928 @default.
- W1569325306 hasConcept C25498285 @default.
- W1569325306 hasConcept C2776914184 @default.
- W1569325306 hasConcept C2776925932 @default.
- W1569325306 hasConcept C2777530519 @default.
- W1569325306 hasConcept C2777542381 @default.
- W1569325306 hasConcept C2777682930 @default.
- W1569325306 hasConcept C2777914695 @default.
- W1569325306 hasConcept C2779134260 @default.
- W1569325306 hasConcept C2779830541 @default.
- W1569325306 hasConcept C2780495277 @default.
- W1569325306 hasConcept C529278444 @default.
- W1569325306 hasConcept C71924100 @default.
- W1569325306 hasConcept C86803240 @default.
- W1569325306 hasConcept C87753298 @default.
- W1569325306 hasConcept C98274493 @default.
- W1569325306 hasConceptScore W1569325306C126322002 @default.
- W1569325306 hasConceptScore W1569325306C142724271 @default.
- W1569325306 hasConceptScore W1569325306C164027704 @default.