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- W1569325886 abstract "Objective To investigate the therapeutic time window of Ligustrazine with Salvia miltiorrhiza and Angelica sinensis Diels in reperfusion injury after focal cerebral ischemia in rats. Methods Sixty adult male Wistar rats were randomly divided into two groups, the medicine group and saline control group. The two groups were once more divided into middle cerebral artery occlusion (MCAO) 2h, 3h, 4h, 5h, and 6h groups (6/group). A rat model of MCAO was induced by the intraluminal suture method; reperfusion was performed after cerebral ischemia 2h, 3h, 4h, 5h, and 6h, respectively. Following success of MCAO model, each medicine group was administered at 20 minutes before reperfusion after cerebral ischemia,12h and 36h after reperfusion with Ligustrazine 0.35mg/100g plus Salvia miltiorrhiza 200mg/100g plus Angelica sinensis Diels 165mg/100g and isotonic saline solution 1.5mL,and the control group was administered isotonic saline solution 1.5mL.The survival rate of rats was calculated. Meanwhile, the volumes of cerebral infarction by TTC staining, neurological functional deficits were evaluated and cerebral blood flow was measured at 48h after the reperfusion. Results The survival rates of rats in the two group rats were 70% and 40%. The survival rates of rats in the medicine group for five MCAO times were: 100.0%, 83.3%, 83.3%, 66.7% and 16.7%. And the control group: 83.3%, 50.0%, 33.3%, 16.7%, and 16.7%, respectively. Neurological deficit scores in the medicine group rats were: 2.12± 0.38, 2.52± 0.45, 2.69± 0.51, 3.39±0.51, and 4.63± 0.71. And control group were: 3.81± 0.22, 3.82± 0.33, 4.13± 0.12, 4.31±0.42, and 4.51±0.31, respectively. The relative magnitude of cerebral blood flow in the medicine group rats were: (155±31.42), (139±39.53), (129±31.69), (113±29.98), and (83±41.63) %. And the control group were: (93± 519.12), (87±29.22), (81±29.20), (73± 21.19) and (79±39.53)%. The volumes of cerebral infarction in the medicine group rats were: (128.2±65.2), (183.1±78.2), (221.5±41.3), (347.1±37.7), and (403.12±61.8) mm3. And the control group were: (183.2±71.3), (249.6± 37.2), (347.5±14.4), (381.3±12.0) and (415.61±32.7) mm3. There was statistical significance of all surveying between the medicine and control group (P＜0.05 or P＜0.01) in different times of MCAO (except MCAO 6h group). Conclusion The neuroprotective effect of combined Ligustrazine with Salvia miltiorrhiza and Angelica sinensis Diels on focal cerebral ischemia/reperfusion injury in rats were 2h to 5h." @default.
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- W1569325886 date "2010-02-10" @default.
- W1569325886 modified "2023-09-28" @default.
- W1569325886 title "川芎嗪-丹参-当归配伍对大鼠脑缺血治疗时间窗的影响" @default.
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