FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1569329462> ?p ?o ?g. }

• W1569329462 abstract "An injury to the cervical region of the spinal cord can cause paralysis affecting all fourlimbs, termed tetraplegia. People with tetraplegia also have paralysis or impaired functionof the major respiratory muscles, namely the diaphragm and intercostal and abdominalmuscles. This often reduces respiratory function, with associated respiratory complications aleading cause of morbidity and mortality for this population. Abdominal Functional ElectricalStimulation (AFES), the application of electrical pulses to the abdominal muscles causingthem to contract, has been shown to improve respiratory function in tetraplegia. Despite thesepositive results, further work is needed to establish AFES as a standard clinical treatment.The aim of this thesis is to support the clinical introduction of AFES. This was achievedby addressing two primary objectives. Firstly, the development of new technologies andprotocols to optimise AFES for use in a clinical setting. Secondly, the clinical evaluation ofthese technologies and protocols with tetraplegic patients.For research purposes, AFES has typically been applied manually, requiring an operatorto synchronise stimulation with respiratory activity. One important step necessary for theclinical introduction of AFES is the development of an automated AFES device that canapply stimulation in synchrony with the users respiratory activity, with different stimulationparameters applied for different breath types such as a quiet breath and a cough. In thisthesis, the signal from a non-intrusive respiratory effort belt, worn around the chest, wasused to develop a statistical classifcation algorithm capable of classifying respiratory activityin real-time, and applying AFES in synchrony with the user's respiratory activity. Theeffectiveness of AFES can also be enhanced by stimulating at the abdominal muscle motorpoints. In this thesis the positions of the abdominal motor points were located systematicallyfor the frst time, in ten able bodied and five tetraplegic participants.To aid the clinical introduction of AFES it is necessary to establish the patient groups whowould benefit most from this intervention, and to develop appropriate clinical protocols.This is addressed in two clinical studies, where the feasibility and effectiveness of AFES toimprove the respiratory function of the acute ventilator dependant and sub-acute tetraplegicpopulations was demonstrated. In the first study, conducted with 10 acute ventilatordependant tetraplegics, AFES was applied on alternate weeks for a total duration of eightweeks. This resulted in acute improvements in breathing and led to a longitudinal increase in respiratory function over the study duration. It was found that participants weaned frommechanical ventilation on average 11 days faster than matched historic controls.Previous work, which investigated the effect of a three week AFES training programme onthe respiratory function of people with sub-acute tetraplegia, suggested that an extendedAFES training programme may be more effective. In the second clinical study in this thesis,a continuous eight week AFES training protocol (combined with a six week control period)was evaluated with three sub-acute tetraplegic participants. The application of AFES ledto an acute increase in respiratory function, with a longitudinal improvement in respiratoryfunction observed throughout the study. In a single participant case study, the feasibilityof combining AFES with assisted coughing delivered by mechanical insufflation-exsufflationwas demonstrated for the first time. This was shown to lead to an acute improvement inrespiratory function at six of the eight assessment sessions, indicating that this techniquecould be used to aid secretion removal.This thesis highlights the feasibility and effectiveness of AFES to improve the respiratoryfunction of the acute ventilator dependant and sub-acute tetraplegic populations. The clinicalprotocols that enable AFES to be used with these patient groups, and the technologicaldevelopments detailed throughout this thesis, are an important step towards the introductionof AFES as a regular treatment modality." @default.
• W1569329462 created "2016-06-24" @default.
• W1569329462 creator A5035497082 @default.
• W1569329462 date "2014-01-01" @default.
• W1569329462 modified "2023-09-28" @default.
• W1569329462 title "Abdominal functional electrical stimulation to improve respiratory function in acute and sub-acute tetraplegia" @default.
• W1569329462 cites W1488022313 @default.
• W1569329462 cites W1508003593 @default.
• W1569329462 cites W1574857530 @default.
• W1569329462 cites W1644997609 @default.
• W1569329462 cites W167203338 @default.
• W1569329462 cites W1753018013 @default.
• W1569329462 cites W1964046679 @default.
• W1569329462 cites W1973193840 @default.
• W1569329462 cites W1974862613 @default.
• W1569329462 cites W1975016180 @default.
• W1569329462 cites W1978535474 @default.
• W1569329462 cites W1979485498 @default.
• W1569329462 cites W1980883816 @default.
• W1569329462 cites W1983418664 @default.
• W1569329462 cites W1983813215 @default.
• W1569329462 cites W1987940417 @default.
• W1569329462 cites W1988635931 @default.
• W1569329462 cites W1988952750 @default.
• W1569329462 cites W1989471045 @default.
• W1569329462 cites W1997117410 @default.
• W1569329462 cites W2001408980 @default.
• W1569329462 cites W2003907616 @default.
• W1569329462 cites W2008215444 @default.
• W1569329462 cites W2008777175 @default.
• W1569329462 cites W2011304700 @default.
• W1569329462 cites W2012924135 @default.
• W1569329462 cites W2013026852 @default.
• W1569329462 cites W2015075214 @default.
• W1569329462 cites W2015795623 @default.
• W1569329462 cites W2018728222 @default.
• W1569329462 cites W2019100367 @default.
• W1569329462 cites W2019243691 @default.
• W1569329462 cites W2020182818 @default.
• W1569329462 cites W2020980394 @default.
• W1569329462 cites W2028349505 @default.
• W1569329462 cites W2029621364 @default.
• W1569329462 cites W2031044940 @default.
• W1569329462 cites W2035222887 @default.
• W1569329462 cites W2035831669 @default.
• W1569329462 cites W2036705196 @default.
• W1569329462 cites W2036880089 @default.
• W1569329462 cites W2038306701 @default.
• W1569329462 cites W2039595894 @default.
• W1569329462 cites W2040294915 @default.
• W1569329462 cites W2041010446 @default.
• W1569329462 cites W2042372803 @default.
• W1569329462 cites W2043503982 @default.
• W1569329462 cites W2044092820 @default.
• W1569329462 cites W2045831451 @default.
• W1569329462 cites W2046879523 @default.
• W1569329462 cites W2047147810 @default.
• W1569329462 cites W2048703429 @default.
• W1569329462 cites W2048943564 @default.
• W1569329462 cites W2050889244 @default.
• W1569329462 cites W2051208801 @default.
• W1569329462 cites W2053348218 @default.
• W1569329462 cites W2054644324 @default.
• W1569329462 cites W2054728315 @default.
• W1569329462 cites W2055336281 @default.
• W1569329462 cites W2066593625 @default.
• W1569329462 cites W2071794888 @default.
• W1569329462 cites W2073036883 @default.
• W1569329462 cites W2073340847 @default.
• W1569329462 cites W2074698826 @default.
• W1569329462 cites W2074856832 @default.
• W1569329462 cites W2076374554 @default.
• W1569329462 cites W2077537304 @default.
• W1569329462 cites W2078486462 @default.
• W1569329462 cites W2079797922 @default.
• W1569329462 cites W2080017033 @default.
• W1569329462 cites W2080947784 @default.
• W1569329462 cites W2082661656 @default.
• W1569329462 cites W2083203020 @default.
• W1569329462 cites W2084040901 @default.
• W1569329462 cites W2084470784 @default.
• W1569329462 cites W2086382526 @default.
• W1569329462 cites W2090221017 @default.
• W1569329462 cites W2093990877 @default.
• W1569329462 cites W2097514219 @default.
• W1569329462 cites W2097851196 @default.
• W1569329462 cites W2101581362 @default.
• W1569329462 cites W2104105197 @default.
• W1569329462 cites W2105048080 @default.
• W1569329462 cites W2106700665 @default.
• W1569329462 cites W2107031757 @default.
• W1569329462 cites W2107690028 @default.
• W1569329462 cites W2108678383 @default.
• W1569329462 cites W2113729932 @default.
• W1569329462 cites W2116945975 @default.
• W1569329462 cites W2117763132 @default.
• W1569329462 cites W2124016027 @default.
• W1569329462 cites W2124772030 @default.
• W1569329462 cites W2125078269 @default.
• W1569329462 cites W2127534229 @default.

• next