FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1569332884> ?p ?o ?g. }

• W1569332884 endingPage "15490" @default.
• W1569332884 startingPage "15486" @default.
• W1569332884 abstract "Activation of cAMP-dependent protein kinase II by static and dynamic steady-state cAMP levels was studied by reconstituting an in vitro model system composed of hormone-sensitive adenylate cyclase, cyclic nucleotide phosphodiesterase, and cAMP-dependent protein kinase II. The rates of cAMP synthesis were regulated by incubating isolated membranes from AtT20 cells with various concentrations of forskolin. In the presence of 3-methylisobutylxanthine, the rate of protein kinase activation was proportional to the rate at which cAMP was synthesized, and there was a direct relationship between the degree of activation and the level of cAMP produced. The activation profiles of protein kinase generated in the presence of exogenous cAMP or cAMP produced by activation of adenylate cyclase in the absence of cAMP degradation were indistinguishable. Dynamic steady-state levels of cAMP were achieved by incubating the membranes with forskolin in the presence of purified cyclic nucleotide phosphodiesterase. Under these conditions, the apparent activation constant of protein kinase II for cAMP was reduced by 65-75%. This increased sensitivity to activation by cAMP was seen when phosphotransferase activity was measured directly in reaction mixtures containing membranes, protein kinase, and histone H2B or when regulatory and catalytic subunits were first separated by immunoprecipitation of holoenzyme and regulatory subunits with specific anti-serum. Our results are consistent with the hypothesis that rapid cAMP turnover may function as a mechanism for amplifying hormonal signals which use the cAMP-dependent protein kinase system." @default.
• W1569332884 created "2016-06-24" @default.
• W1569332884 creator A5019730885 @default.
• W1569332884 creator A5076993179 @default.
• W1569332884 creator A5079330226 @default.
• W1569332884 date "1986-11-01" @default.
• W1569332884 modified "2023-10-16" @default.
• W1569332884 title "Enhanced activation of cAMP-dependent protein kinase by rapid synthesis and degradation of cAMP." @default.
• W1569332884 cites W1451094190 @default.
• W1569332884 cites W1500214274 @default.
• W1569332884 cites W1511496806 @default.
• W1569332884 cites W1523111058 @default.
• W1569332884 cites W1525213463 @default.
• W1569332884 cites W1539638985 @default.
• W1569332884 cites W1565969009 @default.
• W1569332884 cites W1576399086 @default.
• W1569332884 cites W1578065846 @default.
• W1569332884 cites W1592393761 @default.
• W1569332884 cites W1593025965 @default.
• W1569332884 cites W1595140410 @default.
• W1569332884 cites W1602379280 @default.
• W1569332884 cites W1658269687 @default.
• W1569332884 cites W1956627733 @default.
• W1569332884 cites W1975286415 @default.
• W1569332884 cites W1977825470 @default.
• W1569332884 cites W1984982392 @default.
• W1569332884 cites W1989438081 @default.
• W1569332884 cites W1991218053 @default.
• W1569332884 cites W1992642548 @default.
• W1569332884 cites W2001336242 @default.
• W1569332884 cites W2002399107 @default.
• W1569332884 cites W2010820226 @default.
• W1569332884 cites W2010981679 @default.
• W1569332884 cites W2020841780 @default.
• W1569332884 cites W2047967376 @default.
• W1569332884 cites W2049622511 @default.
• W1569332884 cites W2067322774 @default.
• W1569332884 cites W207058564 @default.
• W1569332884 cites W2073669343 @default.
• W1569332884 cites W2085214862 @default.
• W1569332884 cites W2091705584 @default.
• W1569332884 cites W2098477357 @default.
• W1569332884 cites W2102131116 @default.
• W1569332884 cites W2125067130 @default.
• W1569332884 cites W2169503005 @default.
• W1569332884 cites W2173317528 @default.
• W1569332884 cites W2175348340 @default.
• W1569332884 cites W2399866381 @default.
• W1569332884 cites W27976590 @default.
• W1569332884 cites W2869189 @default.
• W1569332884 cites W4250847391 @default.
• W1569332884 cites W4251607962 @default.
• W1569332884 cites W63571119 @default.
• W1569332884 cites W70893513 @default.
• W1569332884 doi "https://doi.org/10.1016/s0021-9258(18)66738-9" @default.
• W1569332884 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2430960" @default.
• W1569332884 hasPublicationYear "1986" @default.
• W1569332884 type Work @default.
• W1569332884 sameAs 1569332884 @default.
• W1569332884 citedByCount "16" @default.
• W1569332884 countsByYear W15693328842013 @default.
• W1569332884 countsByYear W15693328842014 @default.
• W1569332884 countsByYear W15693328842015 @default.
• W1569332884 countsByYear W15693328842017 @default.
• W1569332884 crossrefType "journal-article" @default.
• W1569332884 hasAuthorship W1569332884A5019730885 @default.
• W1569332884 hasAuthorship W1569332884A5076993179 @default.
• W1569332884 hasAuthorship W1569332884A5079330226 @default.
• W1569332884 hasBestOaLocation W15693328841 @default.
• W1569332884 hasConcept C12554922 @default.
• W1569332884 hasConcept C184235292 @default.
• W1569332884 hasConcept C185592680 @default.
• W1569332884 hasConcept C2779679103 @default.
• W1569332884 hasConcept C41008148 @default.
• W1569332884 hasConcept C55493867 @default.
• W1569332884 hasConcept C76155785 @default.
• W1569332884 hasConcept C86803240 @default.
• W1569332884 hasConcept C95444343 @default.
• W1569332884 hasConcept C97029542 @default.
• W1569332884 hasConceptScore W1569332884C12554922 @default.
• W1569332884 hasConceptScore W1569332884C184235292 @default.
• W1569332884 hasConceptScore W1569332884C185592680 @default.
• W1569332884 hasConceptScore W1569332884C2779679103 @default.
• W1569332884 hasConceptScore W1569332884C41008148 @default.
• W1569332884 hasConceptScore W1569332884C55493867 @default.
• W1569332884 hasConceptScore W1569332884C76155785 @default.
• W1569332884 hasConceptScore W1569332884C86803240 @default.
• W1569332884 hasConceptScore W1569332884C95444343 @default.
• W1569332884 hasConceptScore W1569332884C97029542 @default.
• W1569332884 hasIssue "33" @default.
• W1569332884 hasLocation W15693328841 @default.
• W1569332884 hasOpenAccess W1569332884 @default.
• W1569332884 hasPrimaryLocation W15693328841 @default.
• W1569332884 hasRelatedWork W1990580490 @default.
• W1569332884 hasRelatedWork W1991111125 @default.
• W1569332884 hasRelatedWork W2025794474 @default.
• W1569332884 hasRelatedWork W2028157626 @default.
• W1569332884 hasRelatedWork W2058545848 @default.

• next