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• W1569336099 abstract "Autoantibodies are the serological hallmark of autoimmune disease. Though their pathogenic role is debatable, they play an important role in the management of a patient with rheumatic disease. However, due to their presence in the general population as well as in multiple autoimmune diseases, the presence of an autoantibody alone does not make a diagnosis; the result has to be interpreted along with clinical findings. Similarly, the absence of autoantibody does not exclude a disease. The common autoantibodies used in clinical practice include rheumatoid factor, anti-CCP antibodies, antinuclear antibodies (ANAs), anti-neutrophil cytoplasmic antibodies (ANCA) and anti-phospholipid antibodies. Once an autoantibody to a broad antigen is detected in a patient, sub-specificity analysis can improve the utility of the antibody. Autoantibodies are detected in the serum using different assays and results of which can vary; thus, it is important for a clinician to know the method used, its sensitivity and specificity to help in the proper interpretation of the laboratory results. This review will address these issues." @default.
• W1569336099 created "2016-06-24" @default.
• W1569336099 creator A5054123086 @default.
• W1569336099 date "2014-12-01" @default.
• W1569336099 modified "2023-10-13" @default.
• W1569336099 title "Role of autoantibody testing" @default.
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• W1569336099 doi "https://doi.org/10.1016/j.berh.2015.04.010" @default.
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