FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1569338260> ?p ?o ?g. }

• W1569338260 endingPage "8089" @default.
• W1569338260 startingPage "8082" @default.
• W1569338260 abstract "Chorioamniotic infection is a leading cause of preterm premature rupture of fetal membranes (amnion and chorion). Bacterial infection induces an inflammatory response characterized by elevated production of proinflammatory cytokines; the latter activate the production of both PGs that stimulate uterine contractions, and matrix metalloproteinases (MMPs) that degrade the extracellular matrix of the chorioamniotic membranes. The inflammatory response is under the control of cAMP content, which is partly regulated by phosphodiesterases (PDE). In this study, we investigated the role of the PDE4 family in the inflammatory process triggered by LPS in a model of amniochorionic explants. We found that PDE4 family is the major cAMP-PDE expressed in human fetal membranes and that PDE4 activity is increased by LPS treatment. Selective inhibition of PDE4 activity affected LPS signaling, because PDE4 inhibitors (rolipram and/or cilomilast) reduced the release of the proinflammatory cytokine TNF-alpha and increased the release of the anti-inflammatory cytokine IL-10. PDE4 inhibition reduced cyclooxygenase-2 protein expression and PGE(2) production and also modulated MMP-9, a key mediator of the membrane rupture process, by inhibiting pro-MMP-9 mRNA expression and pro-MMP-9 activity. These results demonstrate that the PDE4 family participates in the regulation of the inflammatory response associated with fetal membrane rupture during infection. The PDE4 family may be an appropriate pharmacological target for the management of infection-induced preterm delivery." @default.
• W1569338260 created "2016-06-24" @default.
• W1569338260 creator A5023618895 @default.
• W1569338260 creator A5031857393 @default.
• W1569338260 creator A5035993491 @default.
• W1569338260 creator A5047340343 @default.
• W1569338260 creator A5066106026 @default.
• W1569338260 date "2005-06-15" @default.
• W1569338260 modified "2023-10-18" @default.
• W1569338260 title "Evidence for a Role of Phosphodiesterase 4 in Lipopolysaccharide-Stimulated Prostaglandin E2 Production and Matrix Metalloproteinase-9 Activity in Human Amniochorionic Membranes" @default.
• W1569338260 cites W1481199079 @default.
• W1569338260 cites W1549669942 @default.
• W1569338260 cites W1745264954 @default.
• W1569338260 cites W1965813730 @default.
• W1569338260 cites W1967025802 @default.
• W1569338260 cites W1968171534 @default.
• W1569338260 cites W1968285353 @default.
• W1569338260 cites W1971514676 @default.
• W1569338260 cites W1978414064 @default.
• W1569338260 cites W1988868295 @default.
• W1569338260 cites W1989666280 @default.
• W1569338260 cites W1992777534 @default.
• W1569338260 cites W1995642722 @default.
• W1569338260 cites W2002874752 @default.
• W1569338260 cites W2012033091 @default.
• W1569338260 cites W2023122800 @default.
• W1569338260 cites W2043707891 @default.
• W1569338260 cites W2051526691 @default.
• W1569338260 cites W2051972766 @default.
• W1569338260 cites W2053076206 @default.
• W1569338260 cites W2056199974 @default.
• W1569338260 cites W2060186487 @default.
• W1569338260 cites W2069254124 @default.
• W1569338260 cites W2071714347 @default.
• W1569338260 cites W2073589082 @default.
• W1569338260 cites W2073747179 @default.
• W1569338260 cites W2099058778 @default.
• W1569338260 cites W2099210988 @default.
• W1569338260 cites W2117329473 @default.
• W1569338260 cites W2123066014 @default.
• W1569338260 cites W2128069959 @default.
• W1569338260 cites W2135175953 @default.
• W1569338260 cites W2135759791 @default.
• W1569338260 cites W2142844505 @default.
• W1569338260 cites W2145388421 @default.
• W1569338260 cites W2146858380 @default.
• W1569338260 cites W2148557985 @default.
• W1569338260 cites W2159269771 @default.
• W1569338260 cites W2163394733 @default.
• W1569338260 cites W2166218639 @default.
• W1569338260 cites W2341138542 @default.
• W1569338260 cites W4231581694 @default.
• W1569338260 cites W4244773895 @default.
• W1569338260 cites W4293247451 @default.
• W1569338260 cites W957301491 @default.
• W1569338260 doi "https://doi.org/10.4049/jimmunol.174.12.8082" @default.
• W1569338260 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15944316" @default.
• W1569338260 hasPublicationYear "2005" @default.
• W1569338260 type Work @default.
• W1569338260 sameAs 1569338260 @default.
• W1569338260 citedByCount "50" @default.
• W1569338260 countsByYear W15693382602013 @default.
• W1569338260 countsByYear W15693382602014 @default.
• W1569338260 countsByYear W15693382602015 @default.
• W1569338260 countsByYear W15693382602016 @default.
• W1569338260 countsByYear W15693382602017 @default.
• W1569338260 countsByYear W15693382602018 @default.
• W1569338260 countsByYear W15693382602019 @default.
• W1569338260 countsByYear W15693382602020 @default.
• W1569338260 countsByYear W15693382602021 @default.
• W1569338260 countsByYear W15693382602022 @default.
• W1569338260 crossrefType "journal-article" @default.
• W1569338260 hasAuthorship W1569338260A5023618895 @default.
• W1569338260 hasAuthorship W1569338260A5031857393 @default.
• W1569338260 hasAuthorship W1569338260A5035993491 @default.
• W1569338260 hasAuthorship W1569338260A5047340343 @default.
• W1569338260 hasAuthorship W1569338260A5066106026 @default.
• W1569338260 hasBestOaLocation W15693382601 @default.
• W1569338260 hasConcept C109523444 @default.
• W1569338260 hasConcept C126322002 @default.
• W1569338260 hasConcept C134018914 @default.
• W1569338260 hasConcept C164027704 @default.
• W1569338260 hasConcept C172680121 @default.
• W1569338260 hasConcept C181199279 @default.
• W1569338260 hasConcept C185592680 @default.
• W1569338260 hasConcept C2776914184 @default.
• W1569338260 hasConcept C2776953305 @default.
• W1569338260 hasConcept C2776958096 @default.
• W1569338260 hasConcept C2777956040 @default.
• W1569338260 hasConcept C2778690821 @default.
• W1569338260 hasConcept C2778754761 @default.
• W1569338260 hasConcept C2779234561 @default.
• W1569338260 hasConcept C2780899479 @default.
• W1569338260 hasConcept C54355233 @default.
• W1569338260 hasConcept C55493867 @default.
• W1569338260 hasConcept C62826618 @default.
• W1569338260 hasConcept C71924100 @default.
• W1569338260 hasConcept C86803240 @default.

• next