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- W1569338520 abstract "Sirs, We thank Dr Kurlen et al. for their thoughtful comments.1 We totally agree with them that the presence of functional gastrointestinal disorders (FGIDs) could reduce the quality of life in children with coeliac disease (CD). In our study, we demonstrated that the presence of psychological disorders was independently associated with FGIDs (P = 0.0001; r = 0.412).2 Psychological factors may have some role in the development of overt symptoms and in the impairment of the quality of life. As suggested by Dr Kurlen et al., an intervention treating FGIDs and/or related psychological disorders could potentially have a positive impact on quality of life. Unfortunately, there is only weak evidence for the efficacy of any medical intervention in children and adolescents with recurrent abdominal pain and irritable bowel syndrome and some evidence that cognitive behavioural therapy may be useful in this group of patients.3, 4 In addition, a more recent Cochrane Review reported that no evidence exists supporting the use of antidepressant medications for the treatment of abdominal pain-related FGIDs in children and adolescents.5 Due to the fact that neither the pathogenesis of FGIDs in children with CD is still clear nor indeed, it is clear whether the symptoms reflect one or many different aetiological pathways, there is an obvious need for further studies which attempt to elucidate this aetiology. Declaration of personal interests: Annamaria Staiano has received support for research or lectures at sponsored meetings from Admiral, Danone, Johnson & Johnson, Movetis and Noos. Declaration of funding interests: None." @default.
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- W1569338520 date "2011-09-20" @default.
- W1569338520 modified "2023-09-25" @default.
- W1569338520 title "Functional gastrointestinal disorders and coeliac disease in adults - negative impact on quality of life: authors’ reply" @default.
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- W1569338520 doi "https://doi.org/10.1111/j.1365-2036.2011.04847.x" @default.
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