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- W1569344395 abstract "Abstract Oligonucleotides carrying a variety of chemical modifications including conjugates are finding increasing applications in therapeutics, diagnostics, functional genomics, proteomics, and as research tools in chemical and molecular biology. The successful synthesis of oligonucleotides primarily depends on the use of appropriately protected nucleoside building blocks including the exocyclic amino groups of the nucleobases, the hydroxyl groups at the 2′‐, 3′‐, and 5′‐positions of the sugar moieties, and the internucleotide phospho‐linkage. This unit is a thoroughly revised update of the previously published version and describes the recent development of various protecting groups that facilitate reliable oligonucleotide synthesis. In addition, various protecting groups for the imide/lactam function of thymine/uracil and guanine, respectively, are described to prevent irreversible nucleobase modifications that may occur in the presence of reagents used in oligonucleotide synthesis. © 2017 by John Wiley & Sons, Inc." @default.
- W1569344395 created "2016-06-24" @default.
- W1569344395 creator A5016676777 @default.
- W1569344395 creator A5066924463 @default.
- W1569344395 creator A5081705509 @default.
- W1569344395 date "2017-06-01" @default.
- W1569344395 modified "2023-10-12" @default.
- W1569344395 title "Nucleobase Protection of Deoxyribo‐ and Ribonucleosides" @default.
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