Matches in SemOpenAlex for { <https://semopenalex.org/work/W156934525> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W156934525 endingPage "41.36" @default.
- W156934525 startingPage "41.36" @default.
- W156934525 abstract "Abstract In clinical trials therapeutic tumor vaccines have failed to provide evidence of efficacy. Based on preclinical tumor models showing that vaccination during homeostasis-driven proliferation improved therapeutic efficacy, we performed a translational phase I/II clinical trial in men with metastatic hormone-refractory adenocarcinoma of the prostate. This strategy has the theoretical advantage that it eliminates regulatory T cells (Treg). Patients were randomized to cohort A, B or C. Cohort A patients (n = 5) received prostate GVAX TM (two prostate cancer cell lines that secrete GM-CSF, Cell Genesys Inc.) vaccination only. Cohort B (n = 5) received cyclophosphamide followed by reinfusion of autologous PBMC and vaccine (GVAX). Cohort C patients (n=5) received same treatment as Cohort B with the addition of fludarabine. We hypothesized that the most lymphopenic patients would have the fewest Treg. While all cohorts showed an increase in the total number and frequency of peripheral Treg, the most lymphopenic patients (cohort C) had the greatest fold increase in peripheral Treg at weeks 2-6 (2.3,1.2,0.7 / p<0.05). Current studies are examining whether adoptive transfer of CD25 depleted PBMC will reduce Treg recovery and improve clinical response. Supported by CA119123, Robert W. Franz, Chiles foundation, Prostate Cancer Foundation and Providence Medical Foundation" @default.
- W156934525 created "2016-06-24" @default.
- W156934525 creator A5017776584 @default.
- W156934525 creator A5018043939 @default.
- W156934525 creator A5018436364 @default.
- W156934525 creator A5020693046 @default.
- W156934525 creator A5025100380 @default.
- W156934525 creator A5029588412 @default.
- W156934525 creator A5047069710 @default.
- W156934525 creator A5047716483 @default.
- W156934525 creator A5048845755 @default.
- W156934525 creator A5051125847 @default.
- W156934525 creator A5057411048 @default.
- W156934525 creator A5067266240 @default.
- W156934525 creator A5078687782 @default.
- W156934525 date "2009-04-01" @default.
- W156934525 modified "2023-09-27" @default.
- W156934525 title "Increased lymphopenia results in higher percentages of FoxP3+ T cells in patients reconstituted by PBMC adoptive transfer and vaccinated (41.36)" @default.
- W156934525 doi "https://doi.org/10.4049/jimmunol.182.supp.41.36" @default.
- W156934525 hasPublicationYear "2009" @default.
- W156934525 type Work @default.
- W156934525 sameAs 156934525 @default.
- W156934525 citedByCount "0" @default.
- W156934525 crossrefType "journal-article" @default.
- W156934525 hasAuthorship W156934525A5017776584 @default.
- W156934525 hasAuthorship W156934525A5018043939 @default.
- W156934525 hasAuthorship W156934525A5018436364 @default.
- W156934525 hasAuthorship W156934525A5020693046 @default.
- W156934525 hasAuthorship W156934525A5025100380 @default.
- W156934525 hasAuthorship W156934525A5029588412 @default.
- W156934525 hasAuthorship W156934525A5047069710 @default.
- W156934525 hasAuthorship W156934525A5047716483 @default.
- W156934525 hasAuthorship W156934525A5048845755 @default.
- W156934525 hasAuthorship W156934525A5051125847 @default.
- W156934525 hasAuthorship W156934525A5057411048 @default.
- W156934525 hasAuthorship W156934525A5067266240 @default.
- W156934525 hasAuthorship W156934525A5078687782 @default.
- W156934525 hasConcept C121608353 @default.
- W156934525 hasConcept C126322002 @default.
- W156934525 hasConcept C137061746 @default.
- W156934525 hasConcept C143998085 @default.
- W156934525 hasConcept C202751555 @default.
- W156934525 hasConcept C203014093 @default.
- W156934525 hasConcept C2776090121 @default.
- W156934525 hasConcept C2778296632 @default.
- W156934525 hasConcept C2779727006 @default.
- W156934525 hasConcept C2780192828 @default.
- W156934525 hasConcept C55493867 @default.
- W156934525 hasConcept C71924100 @default.
- W156934525 hasConcept C72563966 @default.
- W156934525 hasConcept C79484868 @default.
- W156934525 hasConcept C86803240 @default.
- W156934525 hasConcept C8891405 @default.
- W156934525 hasConcept C90924648 @default.
- W156934525 hasConceptScore W156934525C121608353 @default.
- W156934525 hasConceptScore W156934525C126322002 @default.
- W156934525 hasConceptScore W156934525C137061746 @default.
- W156934525 hasConceptScore W156934525C143998085 @default.
- W156934525 hasConceptScore W156934525C202751555 @default.
- W156934525 hasConceptScore W156934525C203014093 @default.
- W156934525 hasConceptScore W156934525C2776090121 @default.
- W156934525 hasConceptScore W156934525C2778296632 @default.
- W156934525 hasConceptScore W156934525C2779727006 @default.
- W156934525 hasConceptScore W156934525C2780192828 @default.
- W156934525 hasConceptScore W156934525C55493867 @default.
- W156934525 hasConceptScore W156934525C71924100 @default.
- W156934525 hasConceptScore W156934525C72563966 @default.
- W156934525 hasConceptScore W156934525C79484868 @default.
- W156934525 hasConceptScore W156934525C86803240 @default.
- W156934525 hasConceptScore W156934525C8891405 @default.
- W156934525 hasConceptScore W156934525C90924648 @default.
- W156934525 hasIssue "1_Supplement" @default.
- W156934525 hasLocation W1569345251 @default.
- W156934525 hasOpenAccess W156934525 @default.
- W156934525 hasPrimaryLocation W1569345251 @default.
- W156934525 hasRelatedWork W2028205875 @default.
- W156934525 hasRelatedWork W2034441290 @default.
- W156934525 hasRelatedWork W2352803447 @default.
- W156934525 hasRelatedWork W2353377845 @default.
- W156934525 hasRelatedWork W2356126764 @default.
- W156934525 hasRelatedWork W2362219779 @default.
- W156934525 hasRelatedWork W2363716681 @default.
- W156934525 hasRelatedWork W2383896650 @default.
- W156934525 hasRelatedWork W941719885 @default.
- W156934525 hasRelatedWork W2128850852 @default.
- W156934525 hasVolume "182" @default.
- W156934525 isParatext "false" @default.
- W156934525 isRetracted "false" @default.
- W156934525 magId "156934525" @default.
- W156934525 workType "article" @default.