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- W1569347170 abstract "Significance Based on several studies, including ours, we estimate that 40–70 million individuals carry a chromosomally integrated copy of the human herpesvirus 6 (HHV-6) genome in every cell of their body. This condition is referred to as inherited chromosomally integrated HHV-6 (iciHHV-6). The regions targeted for integration are telomeres, which play important roles in the self-renewal capacity of cells. Whether iciHHV-6 is associated with disease remains unknown. After conducting a population screen ( n = 20,000), our results indicate that the prevalence of angina is three times greater in iciHHV-6+ subjects relative to iciHHV-6− ones. Furthermore, iciHHV-6+ subjects have shorter telomeres, a result that may explain, at least in part, how iciHHV-6 may contribute to the development of angina." @default.
- W1569347170 created "2016-06-24" @default.
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- W1569347170 date "2015-06-15" @default.
- W1569347170 modified "2023-10-16" @default.
- W1569347170 title "Inherited chromosomally integrated human herpesvirus 6 as a predisposing risk factor for the development of angina pectoris" @default.
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- W1569347170 doi "https://doi.org/10.1073/pnas.1502741112" @default.
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