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• W1569348649 abstract "Background Anaemia affects about a quarter of the world's population. An estimated 50% of anaemic people have anaemia due to iron deficiency. Objectives To assess the safety and efficacy of iron therapies for the treatment of adults with anaemia who are not pregnant or lactating and do not have chronic kidney disease. Search methods We ran the search on 11 July 2013. We searched the Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, EMBASE (Ovid SP), the Cumulative Index to Nursing and Allied Health Literature (CINAHL) Plus (EBSCO Host), the Institute for Scientific Information Web of Science (ISI WOS) Scientific Citation Index (SCI)‐EXPANDED (1970) and Conference Proceedings Citation Index (CPCI)‐Science (1990) and Clinicaltrials.gov; we also screened reference lists. An updated search was run on 24 November 2014 but the results have not yet been incorporated into the review. Selection criteria Two review authors independently selected references for further assessment by going through all titles and abstracts. Further selection was based on review of full‐text articles for selected references. Data collection and analysis Two review authors independently extracted study data. We calculated the risk ratio (RR) with 95% confidence interval (CI) for binary outcomes and the mean difference (MD) or the standardised mean difference (SMD) with 95% CI for continuous outcomes. We performed meta‐analysis when possible, when I2 was less than or equal to 80% using a fixed‐effect or random‐effects model, using Review Manager software. The range of point estimates for individual studies is presented when I2 > 80%. Main results We included in this systematic review 4745 participants who were randomly assigned in 21 trials. Trials were conducted in a wide variety of clinical settings. Most trials included participants with mild to moderate anaemia and excluded participants who were allergic to iron therapy. All trials were at high risk of bias for one or more domains. We compared both oral iron and parenteral iron versus inactive controls and compared different iron preparations. The comparison between oral iron and inactive control revealed no evidence of clinical benefit in terms of mortality (RR 1.05, 95% CI 0.68 to 1.61; four studies, N = 659; very low‐quality evidence). The point estimate of the mean difference in haemoglobin levels in individual studies ranged from 0.3 to 3.1 g/dL higher in the oral iron group than in the inactive control group. The proportion of participants who required blood transfusion was lower with oral iron than with inactive control (RR 0.74, 95% CI 0.55 to 0.99; three studies, N = 546; very low‐quality evidence). Evidence was inadequate for determination of the effect of parenteral iron on mortality versus oral iron (RR 1.49, 95% CI 0.56 to 3.94; 10 studies, N = 2141; very low‐quality evidence) or inactive control (RR 1.04, 95% CI 0.63 to 1.69; six studies, N = 1009; very low‐quality evidence). Haemoglobin levels were higher with parenteral iron than with oral iron (MD ‐0.50 g/dL, 95% CI ‐0.73 to ‐0.27; six studies, N = 769; very low‐quality evidence). The point estimate of the mean difference in haemoglobin levels in individual studies ranged between 0.3 and 3.0 g/dL higher in the parenteral iron group than in the inactive control group. Differences in the proportion of participants requiring blood transfusion between parenteral iron and oral iron groups (RR 0.61, 95% CI 0.24 to 1.58; two studies, N = 371; very low‐quality evidence) or between parenteral iron groups and inactive controls (RR 0.84, 95% CI 0.66 to 1.06; eight studies, N = 1315; very low‐quality evidence) were imprecise. Average blood volume transfused was less in the parenteral iron group than in the oral iron group (MD ‐0.54 units, 95% CI ‐0.96 to ‐0.12; very low‐quality evidence) based on one study involving 44 people. Differences between therapies in quality of life or in the proportion of participants with serious adverse events were imprecise (very low‐quality evidence). No trials reported severe allergic reactions due to parenteral iron, suggesting that these are rare. Adverse effects related to oral iron treatment included nausea, diarrhoea and constipation; most were mild. Comparisons of one iron preparation over another for mortality, haemoglobin or serious adverse events were imprecise. No information was available on quality of life. Thus, little evidence was found to support the use of one preparation or regimen over another. Subgroup analyses did not reveal consistent results; therefore we were unable to determine whether iron is useful in specific clinical situations, or whether iron therapy might be useful for people who are receiving erythropoietin. Authors' conclusions • Very low‐quality evidence suggests that oral iron might decrease the proportion of people who require blood transfusion, and no evidence indicates that it decreases mortality. Oral iron might be useful in adults who can tolerate the adverse events, which are usually mild. • Very low‐quality evidence suggests that intravenous iron results in a modest increase in haemoglobin levels compared with oral iron or inactive control without clinical benefit. • No evidence can be found to show any advantage of one iron preparation or regimen over another. • Additional randomised controlled trials with low risk of bias and powered to measure clinically useful outcomes such as mortality, quality of life and blood transfusion requirements are needed." @default.
• W1569348649 created "2016-06-24" @default.
• W1569348649 creator A5003943960 @default.
• W1569348649 creator A5013463984 @default.
• W1569348649 creator A5038628975 @default.
• W1569348649 creator A5044695496 @default.
• W1569348649 creator A5079079428 @default.
• W1569348649 date "2014-12-31" @default.
• W1569348649 modified "2023-10-17" @default.
• W1569348649 title "Iron therapy in anaemic adults without chronic kidney disease" @default.
• W1569348649 cites W121918203 @default.
• W1569348649 cites W1498732084 @default.
• W1569348649 cites W1591922027 @default.
• W1569348649 cites W162181629 @default.
• W1569348649 cites W1752039509 @default.
• W1569348649 cites W1767814082 @default.
• W1569348649 cites W1899354575 @default.
• W1569348649 cites W1910589512 @default.
• W1569348649 cites W1935398134 @default.
• W1569348649 cites W1947947913 @default.
• W1569348649 cites W1963807393 @default.
• W1569348649 cites W1964846482 @default.
• W1569348649 cites W1967267266 @default.
• W1569348649 cites W1969455341 @default.
• W1569348649 cites W1970247608 @default.
• W1569348649 cites W1975726033 @default.
• W1569348649 cites W1976583465 @default.
• W1569348649 cites W1976620684 @default.
• W1569348649 cites W1977060710 @default.
• W1569348649 cites W1977196012 @default.
• W1569348649 cites W1978073138 @default.
• W1569348649 cites W1978715947 @default.
• W1569348649 cites W1983306435 @default.
• W1569348649 cites W1985540604 @default.
• W1569348649 cites W1990571781 @default.
• W1569348649 cites W1993258922 @default.
• W1569348649 cites W1996330775 @default.
• W1569348649 cites W1997355335 @default.
• W1569348649 cites W1998830996 @default.
• W1569348649 cites W2002598270 @default.
• W1569348649 cites W2003707184 @default.
• W1569348649 cites W2004887543 @default.
• W1569348649 cites W2014970131 @default.
• W1569348649 cites W2019440184 @default.
• W1569348649 cites W2019615641 @default.
• W1569348649 cites W2022004676 @default.
• W1569348649 cites W2026069738 @default.
• W1569348649 cites W2030691970 @default.
• W1569348649 cites W2032658520 @default.
• W1569348649 cites W2039834282 @default.
• W1569348649 cites W2040034550 @default.
• W1569348649 cites W2040474899 @default.
• W1569348649 cites W2041053260 @default.
• W1569348649 cites W2046653163 @default.
• W1569348649 cites W2048837770 @default.
• W1569348649 cites W2059230191 @default.
• W1569348649 cites W2059589866 @default.
• W1569348649 cites W2060869681 @default.
• W1569348649 cites W2061170797 @default.
• W1569348649 cites W2061252994 @default.
• W1569348649 cites W2063528294 @default.
• W1569348649 cites W2066006975 @default.
• W1569348649 cites W2070319126 @default.
• W1569348649 cites W2074273001 @default.
• W1569348649 cites W2075642745 @default.
• W1569348649 cites W2077651822 @default.
• W1569348649 cites W2085502168 @default.
• W1569348649 cites W2086148792 @default.
• W1569348649 cites W2086322354 @default.
• W1569348649 cites W2088095316 @default.
• W1569348649 cites W2091975568 @default.
• W1569348649 cites W2092187244 @default.
• W1569348649 cites W2092480503 @default.
• W1569348649 cites W2097503522 @default.
• W1569348649 cites W2100001962 @default.
• W1569348649 cites W2100551670 @default.
• W1569348649 cites W2102485252 @default.
• W1569348649 cites W2105550280 @default.
• W1569348649 cites W2106051200 @default.
• W1569348649 cites W2106284588 @default.
• W1569348649 cites W2107328434 @default.
• W1569348649 cites W2110658208 @default.
• W1569348649 cites W2113473958 @default.
• W1569348649 cites W2117294447 @default.
• W1569348649 cites W2117734216 @default.
• W1569348649 cites W2118110095 @default.
• W1569348649 cites W2118574514 @default.
• W1569348649 cites W2118577717 @default.
• W1569348649 cites W2122350912 @default.
• W1569348649 cites W2123200029 @default.
• W1569348649 cites W2125206681 @default.
• W1569348649 cites W2125661115 @default.
• W1569348649 cites W2126930838 @default.
• W1569348649 cites W2130192910 @default.
• W1569348649 cites W2134338262 @default.
• W1569348649 cites W2135885870 @default.
• W1569348649 cites W2138962733 @default.
• W1569348649 cites W2139968799 @default.
• W1569348649 cites W2140043294 @default.
• W1569348649 cites W2145093297 @default.

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