Matches in SemOpenAlex for { <https://semopenalex.org/work/W156935181> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W156935181 endingPage "981" @default.
- W156935181 startingPage "972" @default.
- W156935181 abstract "Antiarrhythmic properties of N-acetylprocainamide, an active metabolite of procainamide, were studied in 15 patients who presented with a cardiac arrest or documented sustained ventricular tachycardia. Programmed electrical stimulation studies were performed. All patients tested had inducible ventricular tachycardia by programmed electrical stimulation techniques while off all antiarrhythmic therapy. Patients were then tested on procainamide 1000 mg administered intravenously, and ventricular tachycardia could be provoked in 8 of 10 patients. Twenty-four to 36 hours later, N-acetylprocainamide was administered, intravenously, and programmed stimulation was performed after 20 minutes. N-acetylprocainamide did not significantly change heart rate, mean arterial blood pressure, electrocardiographic intervals, A-H or H-V conduction times. N-acetylprocainamide prevented ventricular tachycardia induction in 6 of 15 patients. The mean serum N-acetylprocainamide levels in the group protected was 15.7±4 μg/ml and 16.2±4 μg/ml in the group not protected. These 6 patients were discharged on N-acetylprocainamide 1.5 grams orally every 8 hours. Three patients have been maintained on chronic N-acetylprocainamide every 8 hours. Three patients have been maintained on chronic N-acetylprocainamide therapy (6±2 months), two patients had breakthrough ventricular tachycardia on follow-up Holter monitoring and alternative therapy was given. N-acetylprocainamide has antiarrhythmic efficacy in preventing induction of ventricular tachycardia by programmed electrical stimulation in a high risk group of patients. On chronic oral therapy, N-acetylprocainamide appears to be well tolerated with antiarrhythmic efficacy that may be enhanced with further upward dose titration." @default.
- W156935181 created "2016-06-24" @default.
- W156935181 creator A5019162195 @default.
- W156935181 creator A5033219628 @default.
- W156935181 creator A5049309264 @default.
- W156935181 creator A5052565105 @default.
- W156935181 creator A5070235463 @default.
- W156935181 creator A5086544485 @default.
- W156935181 date "1986-12-01" @default.
- W156935181 modified "2023-09-26" @default.
- W156935181 title "N-Acetylprocainamide's Antiarrhythmic Action in Patients with Ventricular Tachycardia" @default.
- W156935181 cites W1967539843 @default.
- W156935181 cites W1989809277 @default.
- W156935181 cites W1999276245 @default.
- W156935181 cites W2016607809 @default.
- W156935181 cites W2019154733 @default.
- W156935181 cites W2029991098 @default.
- W156935181 cites W2036944657 @default.
- W156935181 cites W2040502039 @default.
- W156935181 cites W2044097193 @default.
- W156935181 cites W205765438 @default.
- W156935181 cites W2064301676 @default.
- W156935181 cites W2113745107 @default.
- W156935181 cites W2138137823 @default.
- W156935181 cites W2316659685 @default.
- W156935181 cites W2316806745 @default.
- W156935181 cites W2398602046 @default.
- W156935181 cites W2404934226 @default.
- W156935181 cites W2418500397 @default.
- W156935181 doi "https://doi.org/10.1177/000331978603701207" @default.
- W156935181 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2433972" @default.
- W156935181 hasPublicationYear "1986" @default.
- W156935181 type Work @default.
- W156935181 sameAs 156935181 @default.
- W156935181 citedByCount "1" @default.
- W156935181 crossrefType "journal-article" @default.
- W156935181 hasAuthorship W156935181A5019162195 @default.
- W156935181 hasAuthorship W156935181A5033219628 @default.
- W156935181 hasAuthorship W156935181A5049309264 @default.
- W156935181 hasAuthorship W156935181A5052565105 @default.
- W156935181 hasAuthorship W156935181A5070235463 @default.
- W156935181 hasAuthorship W156935181A5086544485 @default.
- W156935181 hasConcept C126322002 @default.
- W156935181 hasConcept C149151106 @default.
- W156935181 hasConcept C164705383 @default.
- W156935181 hasConcept C2776331378 @default.
- W156935181 hasConcept C2777028498 @default.
- W156935181 hasConcept C2777477808 @default.
- W156935181 hasConcept C2778131192 @default.
- W156935181 hasConcept C2780074459 @default.
- W156935181 hasConcept C2780283014 @default.
- W156935181 hasConcept C42219234 @default.
- W156935181 hasConcept C71924100 @default.
- W156935181 hasConceptScore W156935181C126322002 @default.
- W156935181 hasConceptScore W156935181C149151106 @default.
- W156935181 hasConceptScore W156935181C164705383 @default.
- W156935181 hasConceptScore W156935181C2776331378 @default.
- W156935181 hasConceptScore W156935181C2777028498 @default.
- W156935181 hasConceptScore W156935181C2777477808 @default.
- W156935181 hasConceptScore W156935181C2778131192 @default.
- W156935181 hasConceptScore W156935181C2780074459 @default.
- W156935181 hasConceptScore W156935181C2780283014 @default.
- W156935181 hasConceptScore W156935181C42219234 @default.
- W156935181 hasConceptScore W156935181C71924100 @default.
- W156935181 hasIssue "12" @default.
- W156935181 hasLocation W1569351811 @default.
- W156935181 hasLocation W1569351812 @default.
- W156935181 hasOpenAccess W156935181 @default.
- W156935181 hasPrimaryLocation W1569351811 @default.
- W156935181 hasRelatedWork W156935181 @default.
- W156935181 hasRelatedWork W1977853756 @default.
- W156935181 hasRelatedWork W2006757545 @default.
- W156935181 hasRelatedWork W2015332319 @default.
- W156935181 hasRelatedWork W2032388720 @default.
- W156935181 hasRelatedWork W2055108451 @default.
- W156935181 hasRelatedWork W2086680318 @default.
- W156935181 hasRelatedWork W2413420131 @default.
- W156935181 hasRelatedWork W3141742274 @default.
- W156935181 hasRelatedWork W2181418619 @default.
- W156935181 hasVolume "37" @default.
- W156935181 isParatext "false" @default.
- W156935181 isRetracted "false" @default.
- W156935181 magId "156935181" @default.
- W156935181 workType "article" @default.