FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1569355420> ?p ?o ?g. }

• W1569355420 endingPage "408" @default.
• W1569355420 startingPage "400" @default.
• W1569355420 abstract "Object The placement of deep brain stimulation (DBS) leads in adults is traditionally performed using physiological confirmation of lead location in the awake patient. Most children are unable to tolerate awake surgery, which poses a challenge for intraoperative confirmation of lead location. The authors have developed an interventional MRI (iMRI)–guided procedure to allow for real-time anatomical imaging, with the goal of achieving very accurate lead placement in patients who are under general anesthesia. Methods Six pediatric patients with primary dystonia were prospectively enrolled. Patients were candidates for surgery if they had marked disability and medical therapy had been ineffective. Five patients had the DYT1 mutation, and mean age at surgery was 11.0 ± 2.8 years. Patients underwent bilateral globus pallidus internus (GPi, n = 5) or sub-thalamic nucleus (STN, n = 1) DBS. The leads were implanted using a novel skull-mounted aiming device in conjunction with dedicated software (ClearPoint system), used within a 1.5-T diagnostic MRI unit in a radiology suite, without physiological testing. The Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS) was used at baseline, 6 months, and 12 months postoperatively. Further measures included lead placement accuracy, quality of life, adverse events, and stimulation settings. Results A single brain penetration was used for placement of all 12 leads. The mean difference (± SD) between the intended target location and the actual lead location, in the axial plane passing through the intended target, was 0.6 ± 0.5 mm, and the mean surgical time (leads only) was 190 ± 26 minutes. The mean percent improvement in the BFMDRS movement scores was 86.1% ± 12.5% at 6 months (n = 6, p = 0.028) and 87.6% ± 19.2% at 12 months (p = 0.028). The mean stimulation settings at 12 months were 3.0 V, 83 μsec, 135 Hz for GPi DBS, and 2.1 V, 60 μsec, 145 Hz for STN DBS). There were no serious adverse events. Conclusions Interventional MRI–guided DBS using the ClearPoint system was extremely accurate, provided real-time confirmation of DBS placement, and could be used in any diagnostic MRI suite. Clinical outcomes for pediatric dystonia are comparable with the best reported results using traditional frame-based stereotaxy. Clinical trial registration no.: NCT00792532 ( ClinicalTrials.gov )." @default.
• W1569355420 created "2016-06-24" @default.
• W1569355420 creator A5007800649 @default.
• W1569355420 creator A5019667316 @default.
• W1569355420 creator A5024860464 @default.
• W1569355420 creator A5045171549 @default.
• W1569355420 creator A5053835435 @default.
• W1569355420 creator A5086042587 @default.
• W1569355420 date "2014-10-01" @default.
• W1569355420 modified "2023-09-29" @default.
• W1569355420 title "Interventional MRI–guided deep brain stimulation in pediatric dystonia: first experience with the ClearPoint system" @default.
• W1569355420 cites W1584813473 @default.
• W1569355420 cites W1952755800 @default.
• W1569355420 cites W1963534390 @default.
• W1569355420 cites W1964469897 @default.
• W1569355420 cites W1977848351 @default.
• W1569355420 cites W1980119890 @default.
• W1569355420 cites W2002478453 @default.
• W1569355420 cites W2017417414 @default.
• W1569355420 cites W2022553955 @default.
• W1569355420 cites W2023751265 @default.
• W1569355420 cites W2059685025 @default.
• W1569355420 cites W2072948420 @default.
• W1569355420 cites W2074461496 @default.
• W1569355420 cites W2096406067 @default.
• W1569355420 cites W2101801005 @default.
• W1569355420 cites W2119965098 @default.
• W1569355420 cites W2120678495 @default.
• W1569355420 cites W2127563467 @default.
• W1569355420 cites W2146008329 @default.
• W1569355420 cites W2170515374 @default.
• W1569355420 cites W2171899104 @default.
• W1569355420 cites W2328161078 @default.
• W1569355420 cites W2328435466 @default.
• W1569355420 cites W3027474860 @default.
• W1569355420 doi "https://doi.org/10.3171/2014.6.peds13605" @default.
• W1569355420 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25084088" @default.
• W1569355420 hasPublicationYear "2014" @default.
• W1569355420 type Work @default.
• W1569355420 sameAs 1569355420 @default.
• W1569355420 citedByCount "86" @default.
• W1569355420 countsByYear W15693554202015 @default.
• W1569355420 countsByYear W15693554202016 @default.
• W1569355420 countsByYear W15693554202017 @default.
• W1569355420 countsByYear W15693554202018 @default.
• W1569355420 countsByYear W15693554202019 @default.
• W1569355420 countsByYear W15693554202020 @default.
• W1569355420 countsByYear W15693554202021 @default.
• W1569355420 countsByYear W15693554202022 @default.
• W1569355420 countsByYear W15693554202023 @default.
• W1569355420 crossrefType "journal-article" @default.
• W1569355420 hasAuthorship W1569355420A5007800649 @default.
• W1569355420 hasAuthorship W1569355420A5019667316 @default.
• W1569355420 hasAuthorship W1569355420A5024860464 @default.
• W1569355420 hasAuthorship W1569355420A5045171549 @default.
• W1569355420 hasAuthorship W1569355420A5053835435 @default.
• W1569355420 hasAuthorship W1569355420A5086042587 @default.
• W1569355420 hasBestOaLocation W15693554201 @default.
• W1569355420 hasConcept C111919701 @default.
• W1569355420 hasConcept C114793014 @default.
• W1569355420 hasConcept C118552586 @default.
• W1569355420 hasConcept C126322002 @default.
• W1569355420 hasConcept C126838900 @default.
• W1569355420 hasConcept C127313418 @default.
• W1569355420 hasConcept C141071460 @default.
• W1569355420 hasConcept C143409427 @default.
• W1569355420 hasConcept C152086174 @default.
• W1569355420 hasConcept C176700471 @default.
• W1569355420 hasConcept C2777093003 @default.
• W1569355420 hasConcept C2777319143 @default.
• W1569355420 hasConcept C2778261627 @default.
• W1569355420 hasConcept C2778542668 @default.
• W1569355420 hasConcept C2778559928 @default.
• W1569355420 hasConcept C2779134260 @default.
• W1569355420 hasConcept C2779734285 @default.
• W1569355420 hasConcept C2780112193 @default.
• W1569355420 hasConcept C2989005 @default.
• W1569355420 hasConcept C41008148 @default.
• W1569355420 hasConcept C71924100 @default.
• W1569355420 hasConcept C99508421 @default.
• W1569355420 hasConceptScore W1569355420C111919701 @default.
• W1569355420 hasConceptScore W1569355420C114793014 @default.
• W1569355420 hasConceptScore W1569355420C118552586 @default.
• W1569355420 hasConceptScore W1569355420C126322002 @default.
• W1569355420 hasConceptScore W1569355420C126838900 @default.
• W1569355420 hasConceptScore W1569355420C127313418 @default.
• W1569355420 hasConceptScore W1569355420C141071460 @default.
• W1569355420 hasConceptScore W1569355420C143409427 @default.
• W1569355420 hasConceptScore W1569355420C152086174 @default.
• W1569355420 hasConceptScore W1569355420C176700471 @default.
• W1569355420 hasConceptScore W1569355420C2777093003 @default.
• W1569355420 hasConceptScore W1569355420C2777319143 @default.
• W1569355420 hasConceptScore W1569355420C2778261627 @default.
• W1569355420 hasConceptScore W1569355420C2778542668 @default.
• W1569355420 hasConceptScore W1569355420C2778559928 @default.
• W1569355420 hasConceptScore W1569355420C2779134260 @default.
• W1569355420 hasConceptScore W1569355420C2779734285 @default.
• W1569355420 hasConceptScore W1569355420C2780112193 @default.

• next