FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1569364577> ?p ?o ?g. }

• W1569364577 endingPage "1223" @default.
• W1569364577 startingPage "1210" @default.
• W1569364577 abstract "Summary Background Remission and response are the main outcomes to evaluate the efficacy of new treatments for Crohn’s disease (CD). Aim To explain variation of remission and response rates in active luminal CD. Methods We studied control patients from trials of biological therapies through articles retrieved by MEDLINE search (from 1997 to 2007) and by bibliography review. Thousand nine hundred and thirteen control patients from 28 trials were identified; data were extracted by three independent observers and pooled by DerSimonian and Laird random effect model; factors influencing remission and clinical response were explored by metaregression for aggregated data. Results The pooled control rates of remission and response were 17% and 33%, respectively, both with significant heterogeneity among studies ( P < 0.0001). At metaregression, the time of primary outcome evaluation was associated with remission, whereas the trial’s criteria for defining response and publication year were predictors of response. CDAI score, CRP levels or other clinical variables related with disease activity or concomitant medications were not significant factors. Conclusions Populations used as ‘add‐on’ treatment comparator in trials of biological therapies for active luminal CD are poorly characterized and outcomes are heterogeneous. Planning of future trials will require better description of patients and concomitant therapies, blinding of outcome assessors and homogeneous criteria of outcome definition." @default.
• W1569364577 created "2016-06-24" @default.
• W1569364577 creator A5001960678 @default.
• W1569364577 creator A5005609886 @default.
• W1569364577 creator A5007719681 @default.
• W1569364577 creator A5008838958 @default.
• W1569364577 creator A5010511271 @default.
• W1569364577 creator A5056479414 @default.
• W1569364577 creator A5081128707 @default.
• W1569364577 creator A5088248608 @default.
• W1569364577 date "2008-03-14" @default.
• W1569364577 modified "2023-10-18" @default.
• W1569364577 title "Meta-analysis: remission and response from control arms of randomized trials of biological therapies for active luminal Crohn’s disease" @default.
• W1569364577 cites W186268426 @default.
• W1569364577 cites W1932744652 @default.
• W1569364577 cites W1964785646 @default.
• W1569364577 cites W1966122948 @default.
• W1569364577 cites W1971331597 @default.
• W1569364577 cites W1979227937 @default.
• W1569364577 cites W1982279452 @default.
• W1569364577 cites W1986215651 @default.
• W1569364577 cites W1995620440 @default.
• W1569364577 cites W2000500639 @default.
• W1569364577 cites W2001681806 @default.
• W1569364577 cites W2002451630 @default.
• W1569364577 cites W2002883352 @default.
• W1569364577 cites W2005275461 @default.
• W1569364577 cites W2005846527 @default.
• W1569364577 cites W2017295150 @default.
• W1569364577 cites W2017443683 @default.
• W1569364577 cites W2022253360 @default.
• W1569364577 cites W2036242475 @default.
• W1569364577 cites W2058250733 @default.
• W1569364577 cites W2059775920 @default.
• W1569364577 cites W2083976498 @default.
• W1569364577 cites W2090198994 @default.
• W1569364577 cites W2098638622 @default.
• W1569364577 cites W2107328434 @default.
• W1569364577 cites W2116802019 @default.
• W1569364577 cites W2118232932 @default.
• W1569364577 cites W2118877038 @default.
• W1569364577 cites W2120419234 @default.
• W1569364577 cites W2121609590 @default.
• W1569364577 cites W2122516118 @default.
• W1569364577 cites W2123934318 @default.
• W1569364577 cites W2125647281 @default.
• W1569364577 cites W2131727319 @default.
• W1569364577 cites W2138223843 @default.
• W1569364577 cites W2152026434 @default.
• W1569364577 cites W2153043827 @default.
• W1569364577 cites W2162766966 @default.
• W1569364577 cites W2164237757 @default.
• W1569364577 cites W2164861161 @default.
• W1569364577 cites W2166360124 @default.
• W1569364577 cites W2170521505 @default.
• W1569364577 cites W2321453230 @default.
• W1569364577 cites W3149527659 @default.
• W1569364577 cites W4237219301 @default.
• W1569364577 doi "https://doi.org/10.1111/j.1365-2036.2008.03681.x" @default.
• W1569364577 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18346185" @default.
• W1569364577 hasPublicationYear "2008" @default.
• W1569364577 type Work @default.
• W1569364577 sameAs 1569364577 @default.
• W1569364577 citedByCount "18" @default.
• W1569364577 countsByYear W15693645772012 @default.
• W1569364577 countsByYear W15693645772013 @default.
• W1569364577 countsByYear W15693645772014 @default.
• W1569364577 countsByYear W15693645772017 @default.
• W1569364577 countsByYear W15693645772018 @default.
• W1569364577 countsByYear W15693645772021 @default.
• W1569364577 countsByYear W15693645772023 @default.
• W1569364577 crossrefType "journal-article" @default.
• W1569364577 hasAuthorship W1569364577A5001960678 @default.
• W1569364577 hasAuthorship W1569364577A5005609886 @default.
• W1569364577 hasAuthorship W1569364577A5007719681 @default.
• W1569364577 hasAuthorship W1569364577A5008838958 @default.
• W1569364577 hasAuthorship W1569364577A5010511271 @default.
• W1569364577 hasAuthorship W1569364577A5056479414 @default.
• W1569364577 hasAuthorship W1569364577A5081128707 @default.
• W1569364577 hasAuthorship W1569364577A5088248608 @default.
• W1569364577 hasConcept C126322002 @default.
• W1569364577 hasConcept C142724271 @default.
• W1569364577 hasConcept C168563851 @default.
• W1569364577 hasConcept C17744445 @default.
• W1569364577 hasConcept C199539241 @default.
• W1569364577 hasConcept C204243189 @default.
• W1569364577 hasConcept C204787440 @default.
• W1569364577 hasConcept C27081682 @default.
• W1569364577 hasConcept C2771230 @default.
• W1569364577 hasConcept C2779134260 @default.
• W1569364577 hasConcept C2779280984 @default.
• W1569364577 hasConcept C2779384505 @default.
• W1569364577 hasConcept C2779473830 @default.
• W1569364577 hasConcept C535046627 @default.
• W1569364577 hasConcept C71924100 @default.
• W1569364577 hasConcept C95190672 @default.
• W1569364577 hasConceptScore W1569364577C126322002 @default.
• W1569364577 hasConceptScore W1569364577C142724271 @default.

• next