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- W1569368521 abstract "Objective: To evaluate the gene expression of Toll-Like (TLR-2 and TLR-4) receptors and cytokine profile in postmenopausal women with or without metabolic syndrome (MetS). Methods: In this cross-sectional study, 311 Brazilian women (age$45 years and amenorrhea$12 months) were included. Women showing three or more of the following diagnostic criteria were diagnosed as positive for MetS: waist circumference.88 cm, triglycerides$150 mg/dL, HDL cholesterol,50 mg/dL, blood pressure$130/85 mmHg, and fasting glucose$100 mg/dL. The expression of TLR-2 and TLR-4 in peripheral blood was evaluated by RNA extraction and subsequent real time PCR analysis. The cytokine profile, tumor necrosis factor alpha (TNF-a) and interleukins 1b, 6, and 10, were measured by ELISA. Results: The expression of TLR-2 RNA was demonstrated in 32.5% and TLR-4 in 20.6% of the subjects. There was no association between the expression of TLR-2 and TLR-4 and the presence or absence of MetS (P.0.05). A greater production of IL-6 was associated with TLR-2 and TLR-4 expressions and greater production of TNF-a was associated only with TLR-2 expression (P.0.05). Only the lower quartile of IL-10 was associated with the presence of the MetS (P.0.05). Conclusions: TLR-2 and TLR-4 expressions were associated with increased pro-inflammatory cytokines, IL-6 and TNF-a, with no association with biomarkers of MetS. The low concentrations of IL-10 may suggest an anti-inflammatory modulation in postmenopausal women with MetS. Citation: Orsatti CL, Nahas EAP, Nahas-Neto J, Orsatti FL, Giorgi VI, et al. (2014) Evaluation of Toll-Like Receptor 2 and 4 RNA Expression and the Cytokine Profile in Postmenopausal Women with Metabolic Syndrome. PLoS ONE 9(10): e109259. doi:10.1371/journal.pone.0109259 Editor: Andrea Cignarella, University of Padova, Italy Received April 22, 2014; Accepted September 4, 2014; Published October 17, 2014 Copyright: 2014 Orsatti et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability: The authors confirm that all data underlying the findings are fully available without restriction. All relevant data are within the paper. Funding: This study was supported by the Sao Paulo Research Foundation (FAPESP), process number 2009/14884-2 and 2009/18256-6. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing Interests: The authors have declared that no competing interests exist. * Email: claudiorsatti@gmail.com" @default.
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- W1569368521 date "2014-12-01" @default.
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- W1569368521 title "Evaluation of Toll-like Receptor 2 and 4 RNA Expression and the Cytokine Profile in Postmenopausal Women with Metabolic Syndrome" @default.
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