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- W1569386578 abstract "“Aude Sapere” “Dare to Know—Horace The first part of this three-part series deals with the history of the recognition of the origins of cancer in specific, mainly chemical, environmental factors; and the rapid advances made this century in identifying carcinogens and elucidating their modes of action. I will then go on to review, briefly, the most important groups of carcinogenic chemicals, their in-vivo activation and common mode of action. The second article will start with the cytotoxic drugs and demonstrate that the distinction between them and chemical carcinogens is arbitrary. I will also consider co-carcinogens and the carcinogenic action of UV light and the importance of these phenomena in understanding the genesis of cancer. Finally, I will look at the linked processes of resistance to cytotoxic drugs, defences against carcinogens and DNA repair processes which it may be possible to turn to therapeutic advantage." @default.
- W1569386578 created "2016-06-24" @default.
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- W1569386578 date "1982-07-01" @default.
- W1569386578 modified "2023-10-17" @default.
- W1569386578 title "New toxicology: Carcinogenesis I" @default.
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- W1569386578 doi "https://doi.org/10.1016/s0007-0785(82)80031-8" @default.
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